OMP ST:941 ! Escherichia coli K-12 JW0452
Contents
Strain Summary
| Strain Name |
Escherichia coli K-12 JW0452 |
|---|---|
| Synonyms |
BW25113 acrA748(del)::kan, ECK0457 |
| Taxon Information |
|
| Genotype |
DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 acrA748(del)::kan |
| Strain Reference |
|
| Strain availability | |
| Ancestry | |
| Annotated phenotypes |
|
Notes
Phenotype Annotation
| Annotation ID | not | OMP ID | OMP term name | Relative phenotype information | Experimental condition | ECO ID | ECO term name | Reference | Annotation Extension | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
|
OMP_AN:702 |
OMP:0007362 |
Increased resistance to a nucleoside |
Relative to: OMP_AN:701 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:tunicamycin (7.5 ug ml-1) |
CHEBI:29699 tunicamycin |
fitness score = 5.05 | ||||
|
OMP_AN:704 |
OMP:0006041 |
increased resistance to quinolone |
Relative to: OMP_AN:703 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:doxorubicin (1.0 ug ml-1) |
CHEBI:28748 doxorubicin |
fitness score = 4.41 | ||||
|
OMP_AN:706 |
OMP:0007174 |
increased resistance to antimicrobial peptide |
Relative to: OMP_AN:705 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:vancomycin (50 ug ml-1) |
CHEBI:28001 vancomycin |
fitness score = 4.33 | ||||
|
OMP_AN:710 |
OMP:0006058 |
increased resistance to aminoglycoside |
Relative to: OMP_AN:709 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:amikacin (0.1 ug ml-1) |
CHEBI:2637 amikacin |
fitness score = 3.87 | ||||
|
OMP_AN:712 |
OMP:0006045 |
increased resistance to beta-lactam compound |
Relative to: OMP_AN:711 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:ampicillin (1.0 ug ml-1) |
CHEBI:28971 ampicillin |
fitness score = 3.76 | ||||
|
OMP_AN:713 |
OMP:0007377 |
resistant to alkaloid |
Relative to: OMP_AN:685 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:MMS (0.05%) |
CHEBI:25255 MMS |
fitness score = 3.11 | ||||
|
OMP_AN:715 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:714 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:propidium iodide (1 ug ml-1) |
CHEBI:51240 propidium iodide |
fitness score = 3.25 | ||||
|
OMP_AN:717 |
OMP:0007174 |
increased resistance to antimicrobial peptide |
Relative to: OMP_AN:716 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:indolicidin (0.1 ug ml-1) |
CHEBI:80180 indolicidin |
fitness score = 3.38 | ||||
|
OMP_AN:740 |
OMP:0005078 |
increased resistance to alkaline pH stress |
Relative to: OMP_AN:739 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:pH8 |
fitness score = 3.39 | |||||
|
OMP_AN:746 |
OMP:0006067 |
decreased resistance to chloramphenicol |
Relative to: OMP_AN:649 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:chloramphenicol (2.0 ug ml-1) |
CHEBI:17698 chloramphenicol |
fitness score = -20.88 | ||||
|
OMP_AN:747 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:647 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:tetracycline (1 ug ml-1) |
CHEBI:27902 tetracycline |
fitness score = -10.65 | ||||
|
OMP_AN:778 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:653 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:streptonigrin (0.5 ug ml-1) |
CHEBI:9287 streptonigrin |
fitness score = -17.88 | ||||
|
OMP_AN:780 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:668 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:minocycline (1.0 ug ml-1) |
CHEBI:50694 minocycline |
fitness score = -20.08 | ||||
|
OMP_AN:787 |
OMP:0007363 |
decreased resistance to a nucleoside |
Relative to: OMP_AN:657 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:puromycin (25 ug ml-1) |
CHEBI:17939 puromycin |
fitness score = -29.81 | ||||
|
OMP_AN:788 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:665 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:mecillinam (0.12 ug ml-1) |
CHEBI:51208 mecillinam |
fitness score = -6.68 | ||||
|
OMP_AN:793 |
OMP:0005278 |
increased resistance to organic heterocyclic compound |
Relative to: OMP_AN:789 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:novobiocin (6 ug ml-1) |
CHEBI:28368 novobiocin |
fitness score = 3.98 | ||||
|
OMP_AN:794 |
OMP:0005278 |
increased resistance to organic heterocyclic compound |
Relative to: OMP_AN:790 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:thiolactomycin (5 ug ml-1) |
CID:445629 thiolactomycin |
fitness score = 3.97 | ||||
|
OMP_AN:795 |
OMP:0005278 |
increased resistance to organic heterocyclic compound |
Relative to: OMP_AN:791 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:A22 (0.5 ug ml-1) |
CID:16741200 A22 |
fitness score = 3.64 | ||||
|
OMP_AN:796 |
OMP:0005278 |
increased resistance to organic heterocyclic compound |
Relative to: OMP_AN:792 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:paraquat (10.0 ug ml-1) |
CHEBI:34905 paraquat |
fitness score = 3.50 | ||||
|
OMP_AN:808 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:807 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:hydroxyurea (1.0 ug ml-1) |
CHEBI:44423 hydroxyurea |
fitness score = 4.04 | ||||
|
OMP_AN:810 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:809 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:EGTA (0.5 ug ml-1) |
CHEBI:30740 EGTA |
fitness score = 3.70 | ||||
|
OMP_AN:812 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:811 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:EDTA (0.1 ug ml-1) |
CHEBI:42191 EDTA |
fitness score = 3.16 | ||||
|
OMP_AN:814 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:813 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:high cobalt (0.1 ug ml-1) |
CHEBI:27638 Cobalt |
fitness score = 3.04 | ||||
|
OMP_AN:818 |
increased resistance to organic aromatic compound |
Relative to: OMP_AN:817 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:procaine (30 ug ml-1) |
CHEBI:8430 procaine |
fitness score = 6.62 | |||||
|
OMP_AN:821 |
OMP:0007370 |
decreased resistance to an acridine |
Relative to: OMP_AN:820 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:acriflavine (2.0 ug ml-1) |
CHEBI:383703 acriflavine |
fitness score = -14.87 | ||||
|
OMP_AN:823 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:822 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:novobiocin (30 ug ml-1) |
CHEBI:28368 novobiocin |
fitness score = -22.52 | ||||
|
OMP_AN:836 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:835 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:ethidium bromide (50 ug ml-1) |
CHEBI:4883 ethidium bromide |
fitness score = -29.45 | ||||
|
OMP_AN:837 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:689 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:propidium iodide (50 ug ml-1) |
CHEBI:51240 propidium iodide |
fitness score = -35.57 | ||||
|
OMP_AN:839 |
OMP:0005114 |
increased resistance to SDS-EDTA stress |
Relative to: OMP_AN:838 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:SDS (0.5%) / EDTA (0.5 ug ml-1) |
fitness score = -24.81 | |||||
|
OMP_AN:842 |
OMP:0005276 |
decreased resistance to quinolone |
Relative to: OMP_AN:841 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:dibucaine (1.2 ug ml-1) |
CHEBI:247956 dibucaine |
fitness score = -11.20 | ||||
|
OMP_AN:844 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:843 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:doxorubicin (10 ug ml-1) |
CHEBI:28748 doxorubicin |
fitness score = -20.42 | ||||
|
OMP_AN:846 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:845 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:deoxycholate 2.0% |
CHEBI:23614 deoxycholate |
fitness score = -19.63 | ||||
|
OMP_AN:848 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:847 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:SDS 4.0% |
CHEBI:8984 SDS |
fitness score = -19.58 | ||||
|
OMP_AN:850 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:849 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:oxacillin (40 ug ml-1) |
CHEBI:7809 oxacillin |
fitness score = -19.58 | ||||
|
OMP_AN:852 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:851 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:cholate 2.0% |
CHEBI:29747 cholate |
fitness score = -19.42 | ||||
|
OMP_AN:854 |
OMP:0000335 |
decreased resistance to aminopyrimidine |
Relative to: OMP_AN:853 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:trimethoprim (0.4 ug ml-1) |
CHEBI:45924 trimethoprim |
fitness score = -12.52 | ||||
|
OMP_AN:856 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:855 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:mitomycinc (0.1 ug ml-1) |
CHEBI:27504 mitomycinc |
fitness score = -18.34 | ||||
|
OMP_AN:858 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:857 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:taurocholate 1.0% |
CHEBI:36257 taurocholate |
fitness score = -18.14 | ||||
|
OMP_AN:860 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:859 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:clarythromycin (10.0 ug ml-1) |
CID: 84029 clarythromycin |
fitness score = -13.10 | ||||
|
OMP_AN:862 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:861 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:bile 2.0% |
fitness score = -16.63 | |||||
|
OMP_AN:864 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:863 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:spiramycin (20 ug ml-1) |
CHEBI:85260 spiramycin |
fitness score = -16.16 | ||||
|
OMP_AN:866 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:865 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:carbenicillin (1.5 ug ml-1) |
CHEBI:3393 carbenicillin |
fitness score = -7.45 | ||||
|
OMP_AN:869 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:868 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:fusidic acid (50 ug ml-1) |
CHEBI:29013 fusidicacid |
fitness score = -15.49 | ||||
|
OMP_AN:871 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:870 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:doxycycline (1.0 ug ml-1) |
CHEBI:50845 doxycycline |
fitness score = -14.76 | ||||
|
OMP_AN:873 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:872 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:erythromycin (10.0 ug ml-1) |
CHEBI:48923 erythromycin |
fitness score = -14.54 | ||||
|
OMP_AN:874 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:859 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:clarythromycin (10.0 ug ml-1) |
CID: 84029 clarythromycin |
fitness score = -13.09 | ||||
|
OMP_AN:875 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:655 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:minocycline (0.5 ug ml-1) |
CHEBI:50694 minocycline |
fitness score = -11.58 | ||||
|
OMP_AN:876 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:681 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:azithromycin (1.0 ug ml-1) |
CHEBI:2955 azithromycin |
fitness score = -11.15 | ||||
|
OMP_AN:878 |
OMP:0007173 |
decreased resistance to antimicrobial peptide |
Relative to: OMP_AN:877 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:bleomycin (2.0 ug ml-1) |
CHEBI:22907 bleomycin |
fitness score = -7.10 | ||||
|
OMP_AN:880 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:879 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:pyocyanin (1.0 ug ml-1) |
CHEBI:62220 pyocyanin |
fitness score = -7.88 | ||||
|
OMP_AN:884 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:883 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:carbenicillin (1.5 ug ml-1) |
CHEBI:3393 carbenicillin |
fitness score = -7.45 | ||||
|
OMP_AN:886 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:885 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:chloropromazine (24 ug ml-1) |
CHEBI:3647 chloropromazine |
fitness score = -14.14 | ||||
|
OMP_AN:891 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:890 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:taurocholate 0.5% |
CHEBI:36257 taurocholate |
fitness score = -4.64 | ||||
|
OMP_AN:889 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:887 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:PMS (0.05 ug ml-1) |
CHEBI:53396 PMS |
fitness score = -7.07 | ||||
|
OMP_AN:893 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:892 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:ciprofloxacin (0.008 ug ml-1) |
CHEBI:100241 ciprofloxacin |
fitness score = -3.48 | ||||
|
OMP_AN:895 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:894 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:verapamil (1.0 ug ml-1) |
CHEBI:9948 verapamil |
fitness score = -5.93 | ||||
|
OMP_AN:1010 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:1009 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:triton X 0.01% |
CHEBI:9750 triton X |
fitness score = -3.31 | ||||
|
OMP_AN:1012 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:1011 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:nalidixic acid (1.5 ug ml-1) |
CHEBI:100147 nalidixic acid |
fitness score = -3.05 | ||||
|
OMP_AN:1394 |
OMP:0007500 |
decreased resistance to an epoxide |
Relative to: OMP_AN:1393 Genotype differences: +acrA748(del) Condition differences: no differences |
medium:cerulenin (6.0 ug ml-1) |
CHEBI:171741 cerulenin |
fitness score = -4.04 | ||||
Additional Information
Links
References
See Help:References for how to manage references in OMPwiki.
- ↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed OMPwiki page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 2.52 2.53 2.54 2.55 2.56 2.57 Nichols, RJ et al. (2011) Phenotypic landscape of a bacterial cell. Cell 144 143-56 PubMed OMPwiki page
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- OMP:0000335 ! decreased resistance to aminopyrimidine
- OMP:0005078 ! increased resistance to alkaline pH stress
- OMP:0005114 ! increased resistance to SDS-EDTA stress
- OMP:0005276 ! decreased resistance to organic heterocyclic compound
- OMP:0005278 ! increased resistance to organic heterocyclic compound
- OMP:0006036 ! decreased resistance to macrolide
- OMP:0006040 ! decreased resistance to quinolone
- OMP:0006041 ! increased resistance to quinolone
- OMP:0006044 ! decreased resistance to beta-lactam
- OMP:0006045 ! increased resistance to beta-lactam compound
- OMP:0006058 ! increased resistance to aminoglycoside
- OMP:0006061 ! decreased resistance to tetracycline
- OMP:0006067 ! decreased resistance to chloramphenicol
- OMP:0007173 ! decreased resistance to antimicrobial peptide
- OMP:0007174 ! increased resistance to antimicrobial peptide
- OMP:0007249 ! decreased resistance to a chemical
- OMP:0007250 ! increased resistance to a chemical
- OMP:0007362 ! Increased resistance to a nucleoside
- OMP:0007363 ! decreased resistance to a nucleoside
- OMP:0007370 ! decreased resistance to an acridine
- OMP:0007377 ! decreased resistance to alkylating agent
- OMP:0007500 ! decreased resistance to an epoxide
- OMP ST:800 ! Escherichia coli K-12 BW25113 derivatives
