OMP ST:941 ! Escherichia coli K-12 JW0452

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Strain Summary

Strain Name

Escherichia coli K-12 JW0452

Synonyms

BW25113 acrA748(del)::kan, ECK0457

Taxon Information
  • Pangenome: Escherichia coli
  • Subspecies and/or strain: K-12
  • NCBI Taxonomy ID: 83333
Genotype

DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 acrA748(del)::kan

Strain Reference
Strain availability

CGSC

Ancestry

parent:OMP ST:800 ! Escherichia coli K-12 BW25113

Annotated phenotypes


edit table


Notes

Phenotype Annotation

Annotation ID Qualifier OMP ID OMP term name Relative phenotype information Experimental condition ECO ID ECO term name Reference Annotation Extension Notes

OMP_AN:702

OMP:0007362

Increased resistance to a nucleoside

Relative to: OMP_AN:701

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:tunicamycin (7.5 ug ml-1)

PMID:21185072[2]

CHEBI:29699 tunicamycin

fitness score = 5.05

OMP_AN:704

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:703

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxorubicin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:28748 doxorubicin

fitness score = 4.41

OMP_AN:706

OMP:0007174

increased resistance to antimicrobial peptide

Relative to: OMP_AN:705

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:vancomycin (50 ug ml-1)

PMID:21185072[2]

CHEBI:28001 vancomycin

fitness score = 4.33

OMP_AN:710

OMP:0006058

increased resistance to aminoglycoside

Relative to: OMP_AN:709

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:amikacin (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:2637 amikacin

fitness score = 3.87

OMP_AN:712

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:711

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:ampicillin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:28971 ampicillin

fitness score = 3.76

OMP_AN:713

OMP:0007377

resistant to alkaloid

Relative to: OMP_AN:685

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:MMS (0.05%)

PMID:21185072[2]

CHEBI:25255 MMS

fitness score = 3.11

OMP_AN:715

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:714

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:propidium iodide (1 ug ml-1)

PMID:21185072[2]

CHEBI:51240 propidium iodide

fitness score = 3.25

OMP_AN:717

OMP:0007174

increased resistance to antimicrobial peptide

Relative to: OMP_AN:716

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:indolicidin (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:80180 indolicidin

fitness score = 3.38

OMP_AN:740

OMP:0005078

increased resistance to alkaline pH stress

Relative to: OMP_AN:739

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:pH8

PMID:21185072[2]

fitness score = 3.39

OMP_AN:746

OMP:0006067

decreased resistance to chloramphenicol

Relative to: OMP_AN:649

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:chloramphenicol (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:17698 chloramphenicol

fitness score = -20.88

OMP_AN:747

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:647

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:tetracycline (1 ug ml-1)

PMID:21185072[2]

CHEBI:27902 tetracycline

fitness score = -10.65

OMP_AN:778

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:653

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:streptonigrin (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:9287 streptonigrin

fitness score = -17.88

OMP_AN:780

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:668

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:minocycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50694 minocycline

fitness score = -20.08

OMP_AN:787

OMP:0007363

decreased resistance to a nucleoside

Relative to: OMP_AN:657

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:puromycin (25 ug ml-1)

PMID:21185072[2]

CHEBI:17939 puromycin

fitness score = -29.81

OMP_AN:788

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:665

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:mecillinam (0.12 ug ml-1)

PMID:21185072[2]

CHEBI:51208 mecillinam

fitness score = -6.68

OMP_AN:793

OMP:0005278

increased resistance to organic heterocyclic compound

Relative to: OMP_AN:789

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:novobiocin (6 ug ml-1)

PMID:21185072[2]

CHEBI:28368 novobiocin

fitness score = 3.98

OMP_AN:794

OMP:0005278

increased resistance to organic heterocyclic compound

Relative to: OMP_AN:790

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:thiolactomycin (5 ug ml-1)

PMID:21185072[2]

CID:445629 thiolactomycin

fitness score = 3.97

OMP_AN:795

OMP:0005278

increased resistance to organic heterocyclic compound

Relative to: OMP_AN:791

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:A22 (0.5 ug ml-1)

PMID:21185072[2]

[CID:2830968] MreB perturbing compound A22

fitness score = 3.64

OMP_AN:796

OMP:0005278

increased resistance to organic heterocyclic compound

Relative to: OMP_AN:792

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:paraquat (10.0 ug ml-1)

PMID:21185072[2]

CHEBI:34905 paraquat

fitness score = 3.50

OMP_AN:808

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:807

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:hydroxyurea (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:44423 hydroxyurea

fitness score = 4.04

OMP_AN:810

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:809

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:EGTA (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:30740 EGTA

fitness score = 3.70

OMP_AN:812

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:811

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:EDTA (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:42191 EDTA

fitness score = 3.16

OMP_AN:814

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:813

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:high cobalt (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:27638 Cobalt

fitness score = 3.04

OMP_AN:818

OMP:0005347

Relative to: OMP_AN:817

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:procaine (30 ug ml-1)

PMID:21185072[2]

CHEBI:8430 procaine

fitness score = 6.62

OMP_AN:821

OMP:0007370

decreased resistance to an acridine

Relative to: OMP_AN:820

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:acriflavine (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:74728 acriflavine

fitness score = -14.87

OMP_AN:823

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:822

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:novobiocin (30 ug ml-1)

PMID:21185072[2]

CHEBI:28368 novobiocin

fitness score = -22.52

OMP_AN:836

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:835

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:ethidium bromide (50 ug ml-1)

PMID:21185072[2]

CHEBI:4883 ethidium bromide

fitness score = -29.45

OMP_AN:837

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:689

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:propidium iodide (50 ug ml-1)

PMID:21185072[2]

CHEBI:51240 propidium iodide

fitness score = -35.57

OMP_AN:839

OMP:0005114

increased resistance to SDS-EDTA stress

Relative to: OMP_AN:838

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:SDS (0.5%) / EDTA (0.5 ug ml-1)

PMID:21185072[2]

fitness score = -24.81

OMP_AN:842

OMP:0005276

decreased resistance to quinolone

Relative to: OMP_AN:841

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:dibucaine (1.2 ug ml-1)

PMID:21185072[2]

CHEBI:247956 dibucaine

fitness score = -11.20

OMP_AN:844

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:843

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxorubicin (10 ug ml-1)

PMID:21185072[2]

CHEBI:28748 doxorubicin

fitness score = -20.42

OMP_AN:846

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:845

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:deoxycholate 2.0%

PMID:21185072[2]

CHEBI:23614 deoxycholate

fitness score = -19.63

OMP_AN:848

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:847

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:SDS 4.0%

PMID:21185072[2]

CHEBI:8984 SDS

fitness score = -19.58

OMP_AN:850

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:849

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:oxacillin (40 ug ml-1)

PMID:21185072[2]

CHEBI:7809 oxacillin

fitness score = -19.58

OMP_AN:852

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:851

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:cholate 2.0%

PMID:21185072[2]

CHEBI:29747 cholate

fitness score = -19.42

OMP_AN:854

OMP:0000335

decreased resistance to aminopyrimidine

Relative to: OMP_AN:853

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:trimethoprim (0.4 ug ml-1)

PMID:21185072[2]

CHEBI:45924 trimethoprim

fitness score = -12.52

OMP_AN:856

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:855

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:mitomycinc (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:27504 mitomycinc

fitness score = -18.34

OMP_AN:858

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:857

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:taurocholate 1.0%

PMID:21185072[2]

CHEBI:36257 taurocholate

fitness score = -18.14

OMP_AN:860

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:859

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:clarythromycin (10.0 ug ml-1)

PMID:21185072[2]

CID: 84029 clarythromycin

fitness score = -13.10

OMP_AN:862

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:861

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:bile 2.0%

PMID:21185072[2]

CHEBI:22868 bile

fitness score = -16.63

OMP_AN:864

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:863

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:spiramycin (20 ug ml-1)

PMID:21185072[2]

CHEBI:85260 spiramycin

fitness score = -16.16

OMP_AN:866

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:865

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:carbenicillin (1.5 ug ml-1)

PMID:21185072[2]

CHEBI:3393 carbenicillin

fitness score = -7.45

OMP_AN:869

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:868

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:fusidic acid (50 ug ml-1)

PMID:21185072[2]

CHEBI:29013 fusidicacid

fitness score = -15.49

OMP_AN:871

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:870

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxycycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50845 doxycycline

fitness score = -14.76

OMP_AN:873

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:872

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:erythromycin (10.0 ug ml-1)

PMID:21185072[2]

CHEBI:48923 erythromycin

fitness score = -14.54

OMP_AN:874

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:859

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:clarythromycin (10.0 ug ml-1)

PMID:21185072[2]

CID: 84029 clarythromycin

fitness score = -13.09

OMP_AN:875

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:655

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:minocycline (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:50694 minocycline

fitness score = -11.58

OMP_AN:876

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:681

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:azithromycin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:2955 azithromycin

fitness score = -11.15

OMP_AN:878

OMP:0007173

decreased resistance to antimicrobial peptide

Relative to: OMP_AN:877

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:bleomycin (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:22907 bleomycin

fitness score = -7.10

OMP_AN:880

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:879

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:pyocyanin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:62220 pyocyanin

fitness score = -7.88

OMP_AN:884

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:883

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:carbenicillin (1.5 ug ml-1)

PMID:21185072[2]

CHEBI:3393 carbenicillin

fitness score = -7.45

OMP_AN:886

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:885

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:chloropromazine (24 ug ml-1)

PMID:21185072[2]

CHEBI:3647 chloropromazine

fitness score = -14.14

OMP_AN:891

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:890

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:taurocholate 0.5%

PMID:21185072[2]

CHEBI:36257 taurocholate

fitness score = -4.64

OMP_AN:889

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:887

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:PMS (0.05 ug ml-1)

PMID:21185072[2]

CHEBI:53396 PMS

fitness score = -7.07

OMP_AN:893

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:892

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:ciprofloxacin (0.008 ug ml-1)

PMID:21185072[2]

CHEBI:100241 ciprofloxacin

fitness score = -3.48

OMP_AN:895

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:894

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:verapamil (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:9948 verapamil

fitness score = -5.93

OMP_AN:1010

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:1009

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:triton X 0.01%

PMID:21185072[2]

CHEBI:9750 triton X

fitness score = -3.31

OMP_AN:1012

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:1011

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:nalidixic acid (1.5 ug ml-1)

PMID:21185072[2]

CHEBI:100147 nalidixic acid

fitness score = -3.05

OMP_AN:1394

OMP:0007500

decreased resistance to an epoxide

Relative to: OMP_AN:1393

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:cerulenin (6.0 ug ml-1)

PMID:21185072[2]

CHEBI:171741 cerulenin

fitness score = -4.04

OMP_AN:7496

OMP:0005345

Relative to: OMP_AN:7495

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:benzalkonium (25 ug ml-!)

PMID:21185072[2]

CHEBI:3020 benzalkonium

fitness score = -15.35

OMP_AN:7501

OMP:0005345

Relative to: OMP_AN:7500

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:triclosan (0.05 ug ml-1)

PMID:21185072[2]

CHEBI:164200 triclosan

fitness score = -13.63

OMP_AN:7561

OMP:0005347

increased resistance to organic aromatic compounds

Relative to: OMP_AN:7560

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

medium:benzalkonium (1 ug ml-!)

PMID:21185072[2]

CHEBI:3020 benzalkonium

fitness score = 3.22

OMP_AN:28520

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27557

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:A22
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:2830968) A22

  • chemical concentration= 0.5 ug/ml
  • normalized fitness= 3.64

OMP_AN:28521

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27575

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Acriflavine (acriflavinium chloride)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:74728) Acriflavine (acriflavinium chloride)

  • chemical concentration= 10 ug/ml
  • normalized fitness= -14.87

OMP_AN:28522

OMP:0006058

increased resistance to aminoglycoside

Relative to: OMP_AN:27525

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Amikacin sulfate salt (disulfate)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:2638) Amikacin sulfate salt (disulfate)

  • chemical concentration= 0.1 ug/ml
  • normalized fitness= 3.87

OMP_AN:28523

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:27531

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Ampicillin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:28971) Ampicillin

  • chemical concentration= 1 ug/ml
  • normalized fitness= 3.76

OMP_AN:28524

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:27518

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Azithromycin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:2955) Azithromycin

  • chemical concentration= 1 ug/ml
  • normalized fitness= -11.15

OMP_AN:28525

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27514

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Chlorpromazine hydrochloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:3649) Chlorpromazine hydrochloride

  • chemical concentration= 6 uM
  • normalized fitness= -14.14

OMP_AN:28526

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27506

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Doxorubicin hydrochloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:31522) Doxorubicin hydrochloride

  • chemical concentration= 1 ug/ml
  • normalized fitness= 4.41

OMP_AN:28527

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27506

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Doxorubicin hydrochloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:31522) Doxorubicin hydrochloride

  • chemical concentration= 10 ug/ml
  • normalized fitness= -20.42

OMP_AN:28528

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27590

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Fosfomycin (CID:6093162) +Glucose-6-phosphate (CHEBI:4170)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:6093162 + CHEBI:4170) Fosfomycin (CID:6093162) +Glucose-6-phosphate (CHEBI:4170)

  • chemical concentration= 0.05 ug/ml (in 50 mg/ml G6P)
  • normalized fitness= 3.96

OMP_AN:28529

OMP:0007250

increased resistance to a chemical

Relative to: OMP_AN:27512

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Hydroxyurea
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:44423) Hydroxyurea

  • chemical concentration= 1 mM
  • normalized fitness= 4.04

OMP_AN:28530

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27510

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Mitomycin C
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:27504) Mitomycin C

  • chemical concentration= 0.1 ug/ml
  • normalized fitness= -18.34

OMP_AN:28531

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27513

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Phenazine methosulfate (PMS)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:8055) Phenazine methosulfate (PMS)

  • chemical concentration= 0.05 mM
  • normalized fitness= -7.07

OMP_AN:28532

OMP:0007250

increased resistance to a chemical

Relative to: OMP_AN:27574

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Paraquat dichloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:28786) Paraquat dichloride

  • chemical concentration= 5 uM
  • normalized fitness= 3.5

OMP_AN:28533

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:27543

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Streptonigrin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:9287) Streptonigrin

  • chemical concentration= 0.5 ug/ml
  • normalized fitness= -17.88

OMP_AN:28534

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27516

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Thiolactomycin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:445629) Thiolactomycin

  • chemical concentration= 5 uM
  • normalized fitness= 3.97

OMP_AN:28535

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27588

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Triclosan/Irgasan
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:164200) Triclosan/Irgasan

  • chemical concentration= 0.05 ug/ml
  • normalized fitness= -13.63

OMP_AN:28536

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27566

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Vancomycin HCl hydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:9932) Vancomycin HCl hydrate

  • chemical concentration= 50 ug/ml
  • normalized fitness= 4.33

OMP_AN:28537

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27504

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Novobiocin sodium salt
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:31924) Novobiocin sodium salt

  • chemical concentration= 12 ug/ml
  • normalized fitness= 3.98

OMP_AN:28538

OMP:0006057

decreased resistance to aminoglycoside

Relative to: OMP_AN:27527

Genotype differences:

+lacZ4787(del)( +acrA748(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Spectinomycin dihydrochloride pentahydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:9217) Spectinomycin dihydrochloride pentahydrate

  • chemical concentration= 4 ug/ml
  • normalized fitness= -12.05
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Additional Information

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References

See Help:References for how to manage references in OMPwiki.

  1. ↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 2.52 2.53 2.54 2.55 2.56 2.57 2.58 2.59 2.60 2.61 2.62 2.63 2.64 2.65 2.66 2.67 2.68 2.69 2.70 2.71 2.72 2.73 2.74 2.75 2.76 2.77 2.78 2.79 2.80 Nichols, RJ et al. (2011) Phenotypic landscape of a bacterial cell. Cell 144 143-56 PubMed
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