E. coli-to-Cancer Gene-function Atlas (ECGA)

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This data browser queries data from

Jun Xia*, Li-Ya Chiu*, Ralf B. Nehring, María Angélica Bravo Núñez, Qian Mei, Mercedes Perez, Yin Zhai, Devon M. Fitzgerald, John P. Pribis, Yumeng Wang, Chenyue W. Hu, Reid T. Powell, Sandra A. LaBonte, Ali Jalali, Meztli L. Matadamas Guzmán, Alfred M. Lentzsch, Adam T. Szafran, Mohan C. Joshi, Megan Richters, Janet L. Gibson, Ryan L. Frisch, P.J. Hastings, David Bates, Christine Queitsch, Susan G. Hilsenbeck, Cristian Coarfa, James C. Hu, Deborah A. Siegele, Kenneth L. Scott, Han Liang, Michael A. Mancini, Christophe Herman§, Kyle M. Miller§ & Susan M. Rosenberg§，Bacteria-to- human protein networks reveal origins of endogenous DNA damage.

https://www.cell.com/cell/fulltext/S0092-8674(18)31622-2

Shee et al. 2013 eLIFE ^[1] Xia et al. 2016 Science Advances ^[2]

↑ Shee, C et al. (2013) Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife 2 e01222 PubMed OMPwiki page
↑ Xia, J et al. (2016) Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. Sci Adv 2 e1601605 PubMed OMPwiki page

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Select which fields you would like to display: Note: Only the Ecoli genes are clustered and have mutation rates. Only the Human genes have Subcellular localization of N-terminal GFP fusion and Copy-number increase in cancers

Brief table explanation for users.

Gene	Product	DDP Phenotypes	Function	Gene Homologs	Cluster	Normalized mutation rate	Has a human analog?	DNA damage quenched by thiourea?
aaeR	HTH-type transcriptional activator	Phleo	Transcription regulation-DNA binding TF		3		Y
aegA	Putative oxidoreductase- Fe-S subunit	Phleo, H2O2	oxidation reduction	AIFM3, DLD, DPYD, FDXR	1		Y
aroP	Aromatic amino acid transport protein	Phleo, H2O2, AC, ROS	Transporter	SLC7A1, SLC7A11, SLC7A14, SLC7A2, SLC7A3, SLC7A4, SLC7A6, SLC7A7, SLC7A8, SLC7A9	2		Y	N
ascG	HTH-type transcriptional regulator	Phleo, H2O2, RF, ROS	Transcription regulation-DNA binding TF		1		Y	N
atpD	ATP synthase subunit beta	Phleo, DSB, RF	Metabolism		1		Y
bssS	Biofilm regulator BssS	Phleo, RF, AC	Various cellular processes		6		Y
cbtA	Cytoskeleton-binding toxin	Phleo, RF, ROS	Various cellular processes		6
cheA	Chemotaxis protein	Phleo, DSB, RF	Various cellular processes-two component system	PDK2	6		Y
cho	DNA endonuclease	Phleo, H2O2, RF	DNA repair		1		Y
cobS	Adenosylcobinamide-GDP ribazoletransferase	Phleo, DSB	Metabolism		3
csgD	CsgBAC operon transcriptional regulatory protein	Phleo, H2O2, DSB, RF, AC	Transcription regulation-DNA binding TF		2	7.6	Y
cusR	Transcriptional regulatory protein	Phleo, MMC, RF, AC	Transcription regulation-DNA binding TF		6		Y
cyoE	Protoheme IX farnesyltransferase	Phleo, DSB, RF	oxidation reduction	COQ2, COX10	6		Y
dcm	DNA-cytosine methyltransferase	Phleo, RF	DNA replication	DNMT1, TRDMT1	6		Y
ddpD	Probable DD-dipeptide transport ATP-binding protein	Phleo, RF, AC	Transporter-ABC transporter		6		Y
degQ	Periplasmic pH-dependent serine endoprotease	Phleo	Various cellular processes		3
diaA	DnaA initiator-associating protein	Phleo, H2O2, AC, ROS	DNA replication		2		Y	Y
dinB	DNA polymerase IV	Phleo, H2O2, AC, ROS	DNA replication	POLH, POLI, POLK, REV1	2		Y
dinD	DNA-damage-inducible protein D	Phleo, DSB, RF, AC	DNA repair		6	4.5	Y
dinG	Probable ATP-dependent helicase	Phleo, H2O2, MMC, AC	DNA repair	BRIP1	2		Y
dnaB	Replicative DNA helicase	Phleo, H2O2, DSB, RF, AC, ROS	DNA replication		2		Y
dnaX	DNA polymerase III subunit tau	Phleo, DSB, AC	DNA replication	RFC2, RFC3, RFC4, RFC5	6		Y
dusC	tRNA-dihydrouridine(16) synthase	Phleo	oxidation reduction		3		Y
eutM	Ethanolamine utilization protein	Phleo, AC, ROS	Metabolism		6			Y
evgA	Positive transcription regulator	Phleo, RF, AC, ROS	Transcription regulation-DNA binding TF		6		Y	Y
exuT	Hexuronate transporter	Phleo, DSB, RF	Transporter	SLC17A1, SLC17A2, SLC17A3, SLC17A4, SLC17A5, SLC17A6, SLC17A7, SLC17A8, SLC17A9, SLC37A4, SPNS1, SPNS2	3		Y
fdnG	Formate dehydrogenase- nitrate-inducible major subunit	Phleo	oxidation reduction		6		Y
fieF	Ferrous-iron efflux pump	Phleo	Transporter		3		Y
fliF	Flagellar M-ring protein	Phleo, H2O2, DSB	Metabolism		1
glcC	Glc operon transcriptional activator	Phleo	Transcription regulation-DNA binding TF		3		Y
glgA	Glycogen synthase	Phleo, AC	Metabolism		3
guaD	Guanine deaminase	Phleo, RF, ROS	Metabolism		6		Y	Y
gyrB	DNA gyrase subunit B	Phleo	DNA replication		3		Y
hda	DnaA regulatory inactivator	Phleo, H2O2, DSB, AC, ROS	DNA replication		2		Y	N
hemX	Putative uroporphyrinogen-III C-methyltransferase	Phleo, AC	Metabolism		3		Y
hiuH	5-hydroxyisourate hydrolase	Phleo, H2O2	Metabolism		1		Y
hypF	Carbamoyltransferase	Phleo, DSB, RF	Metabolism	YRDC	6	1.0	Y
kdpD	Sensor protein	Phleo, H2O2, DSB	Various cellular processes-two component system		2		Y
manZ	Mannose permease IID component	Phleo, H2O2, ROS	Metabolism		2			N
mdtA	Multidrug resistance protein	Phleo, DSB	Transporter		3		Y
metG	Methionine--tRNA ligase	Phleo, MMC	Various cellular processes-protein biosynthesis	AIMP1, DARS, DARS2, IARS2, LARS, LARS2, MARS, MARS2, YARS	3		Y
mhpE	4-hydroxy-2-oxovalerate aldolase	Phleo, H2O2, DSB, RF, ROS	Metabolism	HMGCL, HMGCLL1	2		Y	Y
mokC	HokC regulatory protein	Phleo, H2O2, RF, AC, ROS	Various cellular processes		2			N
mutS	DNA mismatch-repair protein- mismatch recognition	Phleo, H2O2, DSB, AC	DNA repair	MSH2, MSH3, MSH4, MSH5, MSH6	2		Y
nanT	Putative sialic acid transporter	Phleo, DSB, RF, ROS	Transporter	SLC16A1, SLC22A1, SLC22A10, SLC22A13, SLC22A16, SLC22A2, SLC22A6, SLC22A8, SLC2A10, SLC2A12, SLC2A13, SPNS1, SPNS2, SV2A, SV2B, SVOP, SVOPL	6		Y	Y
nlpI	Lipoprotein	Phleo, AC, ROS	Various cellular processes-cell division		2		Y	N
nudC	NADH pyrophosphatase	Phleo, H2O2, RF, AC	Metabolism		1		Y
panE	2-dehydropantoate 2-reductase	Phleo, RF, AC	Metabolism		6
polA	DNA polymerase I	Phleo, H2O2, DSB	DNA replication	POLN, POLQ	1		Y
polB	DNA polymerase II	Phleo, H2O2, MMC, DSB, RF	DNA replication	POLA1, POLD1, POLE, REV3L	1		Y
ppiC	Peptidyl-prolyl cis-trans isomerase C	Phleo, RF	Metabolism	PIN1, PIN4	3		Y
prfB	Peptide chain release factor 2	Phleo, H2O2, RF, ROS	Various cellular processes-protein biosynthesis	C12orf65, MTRF1, MTRF1L	2		Y	N
prpD	2-methylcitrate dehydratase	Phleo	Metabolism	IRG1	3		Y
rbsD	D-ribose pyranase	Phleo	Metabolism	FUOM	3
recQ	ATP-dependent DNA helicase	Phleo, H2O2, MMC, DSB	DNA repair	BLM, RECQL4	1		Y
recR	Homologous recombination (HR) protein	Phleo, RF	DNA repair and SOS DDR		3		Y
rffH	Glucose-1-phosphate thymidylyltransferase 2	Phleo, RF	Metabolism	EIF2B3, GMPPA, GMPPB	3
rhmT	Inner membrane transport protein	Phleo	Transporter		6		Y
rusA	Crossover junction endodeoxyribonuclease	Phleo, DSB, RF, AC	DNA repair		6	5.0	Y
ruvA	Holliday-junction recognition protein ATP-dependent DNA helicase	Phleo, AC, ROS	DNA repair		2		Y	N
seqA	Negative modulator of initiation of replication	Phleo, H2O2, DSB, AC, ROS	DNA replication		2		Y
ssb	Single-stranded DNA-binding protein	Phleo, H2O2	DNA replication	SSBP1	1		Y
sstT	Serine/threonine transporter	Phleo, DSB, RF	Transporter	SLC1A1, SLC1A3, SLC1A5	1
thiI	tRNA sulfurtransferase	Phleo, DSB, AC	Metabolism		3		Y
thiM	Hydroxyethylthiazole kinase	Phleo	Metabolism		3
topB	DNA topoisomerase 3	Phleo	DNA replication	TOP3A, TOP3B	3	13.8	Y
uspG	Universal stress protein G- stress response	Phleo, H2O2, DSB, AC	Various cellular processes		1		Y
waaA	3-deoxy-D-manno-octulosonic acid transferase	Phleo, DSB, AC	Metabolism		3
waaF	ADP-heptose--LPS heptosyltransferase 2	Phleo, RF, AC	Metabolism		6
waaH	UDP-glucuronate:LPS(HepIII) glycosyltransferase	Phleo, DSB, RF, AC, ROS	Metabolism	ALG5, B3GNTL1, DPM1, GALNT8	6		Y	N
yafZ	Hypothetical protein- unknown function	Phleo, H2O2, RF, AC	Unknown		1
yagL	Unknown function	Phleo, H2O2, DSB, RF, AC, ROS	Unknown		2
yajR	Unknown function- inner-membrane transport protein similarity	Phleo, H2O2, DSB	Unknown	MFSD10, MFSD8, MFSD9, SLC18A2	1	26.3	Y
ybaQ	Uncharacterized HTH-type transcriptional regulator	Phleo, RF	Transcription regulation-DNA binding TF		6		Y
ybbP	Sulfur transfer protein	Phleo, RF, ROS	Transporter		6		Y	N
ybgQ	Unknown function- outer-membrane usher protein similarity	Phleo, H2O2	Unknown		1	35.0
yccT	Unknown function- conserved protein	Phleo, RF	Unknown		3
ydcR	Uncharacterized HTH-type transcriptional regulator	Phleo, H2O2, DSB, RF	Transcription regulation-DNA binding TF	AADAT, ACCS, ACCSL, BCKDK, CCBL1, CCBL2, PDK1, PDK2, PDK3, PDK4, SLC18A3, SLC22A13, SLC22A8, SV2A, TAT, TOP2A, TOP2B	1	6.0	Y
ydfC	Unknown function	Phleo, RF, AC	Unknown		6
ydhB	Uncharacterized HTH-type transcriptional regulator	Phleo, H2O2, DSB	Transcription regulation-DNA binding TF		1		Y
ydhC	Unknown function- inner membrane transport protein similarity	Phleo, RF	Unknown	SLC18A3	3		Y
ydjM	Inner-membrane protein similarity- up-regulated by SOS DNA-damage response	Phleo, H2O2, RF	Unknown		1		Y
ydjY	Unknown function	Phleo, H2O2, MMC, DSB, RF, AC, ROS	Unknown		2			N
yeaO	Unknown function	Phleo, H2O2, AC, ROS	Unknown		2			Y
yecE	Unknown function- conserved protein	Phleo	Unknown		3
yedA	Uncharacterized- inner membrane transporter similarity	Phleo, H2O2	Unknown		1	0.4	Y
yedI	Unknown function- inner membrane protein	Phleo, ROS	Unknown		6		Y	Y
yedQ	Probable diguanylate cyclase	Phleo, H2O2	Metabolism		1		Y
yegI	Unknown function	Phleo, DSB, AC, ROS	Unknown		6	17.5
yehI	Unknown function	Phleo	Unknown		3
yehS	Unknown function	Phleo, H2O2, MMC	Unknown		1
yfaQ	Unknown function	Phleo, RF	Unknown		3
yfeD	Unknown function	Phleo, RF, AC, ROS	Unknown		6			N
yfjS	Unknown function- putative lipoprotein	Phleo, H2O2, RF, AC, ROS	Unknown		2		Y	N
yhbS	Unknown function- N-acetyltransferase similarity	Phleo, AC, ROS	Unknown	NAT8B	2		Y	N
yhcB	Inner membrane protein	Phleo, RF, AC, ROS	oxidation reduction		6		Y	N
yhdP	Unknown function	Phleo, H2O2, DSB	Unknown		1
yhgA	Unknown function	Phleo, H2O2, RF	Unknown		1
yicR	Unknown function- hypothetical protein	Phleo, DSB, RF	Unknown		6
yiiM	Unknown function- putative protein involved in base-analog detoxification	Phleo	Unknown		3		Y
yliF	Unknown function- putative lipoprotein	Phleo, H2O2, MMC, RF	Unknown		1		Y
ynjC	Unknown function- inner membrane ABC transporter permease similarity	Phleo, DSB, RF	Transporter-ABC transporter		3		Y
ypdB	Transcriptional regulatory protein	Phleo, H2O2, DSB, RF	Transcription regulation-DNA binding TF		6		Y
ypdF	Unknown function- aminopeptidase similarity	Phleo, DSB, RF, AC, ROS	Unknown		2		Y	Y
yqgE	Unknown function- putative protein	Phleo	Unknown		3
yqjD	Unknown function	Phleo, RF	Unknown		3
arcB	Aerobic respiration control sensor protein	H2O2, RF	Metabolism		1		Y
bamC	Outer membrane protein assembly factor	H2O2, DSB	Various cellular processes		1		Y
basR	Transcriptional regulatory protein	H2O2	Transcription regulation-DNA binding TF		1		Y
cadA	Lysine decarboxylase- inducible	H2O2, RF	Metabolism		5	5.5, 5.5	Y
corA	Magnesium transport protein	H2O2, DSB, RF, AC, ROS	Transporter		5	16.3	Y	Y
entS	Enterobactin exporter	H2O2, DSB	Transporter		1		Y
eutP	Unknown function- ethanolamine utilization protein similarity	H2O2, MMC, DSB	Unknown		1
fsaB	Fructose-6-phosphate aldolase 2	H2O2	Metabolism		1		Y
ftsK	DNA translocase-chromosome segregation	H2O2, DSB, RF, AC, ROS	Various cellular processes-cell division	MACF1	5		Y	N
hcaR	Hca operon transcriptional activator	H2O2, DSB, RF, AC	Transcription regulation-DNA binding TF		5	1.9	Y
hslU		H2O2, DSB, AC	Various cellular processes	AFG3L2, ATAD1, CLPB, CLPX, FIGNL1, PSMC2, PSMC4, PSMC5, PSMC6, SPG7, YME1L1	3	7.8	Y
leuO	HTH-type transcriptional regulator	H2O2	Transcription regulation-DNA binding TF		1	11.4	Y
lhr	Probable ATP-dependent helicase	H2O2, RF	DNA replication	ASCC3, DDX20, DDX21, DDX27, DDX3X, DDX50, DDX52, DDX54, DDX59, DDX60, DDX60L, EIF4A2, HELQ, HFM1, POLQ, RECQL4, SKIV2L, SKIV2L2, SNRNP200, WRN	1		Y
macB	Macrolide export ATP-binding/permease protein	H2O2, DSB, RF	Transporter-ABC transporter	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC3, ABCC4, ABCC5, ABCC6, ABCC8, ABCC9, ABCD2, ABCD3, ABCD4, ABCE1, ABCF1, ABCF2, ABCF3, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	5	1.8	Y
mcrA	5-methylcytosine-specific restriction enzyme A	H2O2, RF	Various cellular processes-DNA endonuclease		5		Y
mhpR	Mhp operon transcriptional activator	H2O2, DSB, RF, AC	Transcription regulation-DNA binding TF		5	137.5	Y
plaP	Low-affinity putrescine importer	H2O2, DSB, ROS	Transporter		5		Y	Y
rarA	Replication-associated recombination protein A	H2O2, DSB, RF	DNA repair and replication	AFG3L2, CHTF18, FIGNL1, NSF, NVL, PEX1, PSMC1, PSMC2, PSMC4, PSMC5, PSMC6, RFC2, RFC4, RFC5, SPAST, SPATA5L1, VPS4A, VPS4B, WRNIP1	5		Y
recN	Recombinational DNA repair protein	H2O2, RF	DNA repair		1		Y
tatB	Sec-independent protein translocase protein	H2O2, DSB, RF, ROS	Transporter		5		Y	Y
topA	DNA topoisomerase 1	H2O2, DSB, RF, AC, ROS	DNA replication	TOP3A, TOP3B	5		Y
uvrB	Nucleotide excision repair (NER) protein- DNA-damage recognition	H2O2, RF, ROS	DNA repair	DDX17, DDX19A, DDX19B, DDX21, DDX25, DDX4, DDX41, DDX42, DDX5, DDX50, DDX52, DDX59, EIF4A1, EIF4A2, EIF4A3, FANCM, IFIH1	5	20.0	Y
uvrD	DNA helicase II- used in mismatch repair NER anti-RecA/HR	H2O2, DSB, AC	DNA repair	PARPBP	1		Y
yadD	Unknown function	H2O2, DSB, RF, ROS	Unknown		5
yafV	Unknown function- hydrolase similarity	H2O2	Unknown	NIT1, NIT2	5		Y
ybaM	Unknown function	H2O2, DSB, RF	Unknown		5
yeaW	Putative dioxygenase subunit alpha	H2O2, DSB, RF, ROS	oxidation reduction		5		Y	N
yfeR	Uncharacterized HTH-type transcriptional regulator	H2O2, DSB, RF, AC	Transcription regulation-DNA binding TF		5		Y
yhfK	Unknown function	H2O2	Unknown		1
yhgE	Unknown function	H2O2, RF, AC, ROS	Unknown		2			N
ykgM	50S ribosomal protein L31 type B	H2O2, DSB, RF, AC	Various cellular processes-protein biosynthesis		5		Y
yoaA	Unknown function- probable ATP-dependent helicase	H2O2, DSB	Unknown	BRIP1, ERCC2	5		Y
cueO	Blue copper oxidase	MMC, DSB	oxidation reduction		3	0.5	Y
cusA	Cation efflux system protein	DSB, RF	Transporter		3		Y
dnaA	Chromosomal replication initiator protein	DSB, RF	DNA replication		3		Y
flu	Antigen 43	DSB, ROS	Transporter		3		Y	N
folD	Bifunctional protein	DSB	oxidation reduction		3	8.1	Y
grpE	Nucleotide exchange factor	DSB, RF	Various cellular processes	GRPEL1, GRPEL2	6	20.0	Y
hsdR	Type I restriction enzyme EcoKI R DNA endonuclease	DSB, AC, ROS	Various cellular processes-DNA endonuclease	PPFIA1, PPFIA2	3		Y	Y
pepN	Aminopeptidase N	DSB, RF	Metabolism	ANPEP, ENPEP, ERAP1, ERAP2, LNPEP, LTA4H, NPEPPS, RNPEP, RNPEPL1, TRHDE	1		Y
pgrR	HTH-type transcriptional regulator	DSB, RF, AC	Transcription regulation-DNA binding TF		3	33.8	Y
pinE	DNA-invertase from lambdoid prophage e14	DSB, AC, ROS	Various cellular processes		3		Y	N
recF	DNA replication and repair protein	DSB	DNA repair and SOS DDR		3		Y
spoT	Bifunctional (p)ppGpp synthase/hydrolase- stringent response	DSB, RF	"Metabolism-stress response	HDDC3	3		Y
thiG	Thiazole synthase	DSB, RF, AC	Metabolism		3		Y
tufB	Translation elongation factor Tu 2	DSB, RF	Metabolism	EEF1A1, EEF1A2, EEF2, EEFSEC, EFTUD1, EFTUD2, EIF2S3, EIF5B, GFM1, GFM2, GSPT1, GSPT2, GTPBP1, GTPBP2, GUF1, HBS1L, MTIF2, TUFM	3		Y
uvrA	NER protein- DNA-damage recognition	DSB, RF	DNA repair	ABCA1, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB8, ABCC1, ABCC12, ABCC4, ABCC6, ABCC8, ABCC9, ABCE1, ABCG2, ABCG8	3		Y
xanQ	Xanthine permease	DSB, AC, ROS	Transporter		3		Y	Y
xdhA	Xanthine dehydrogenase molybdenum-binding subunit	DSB, RF, ROS	Metabolism		3		Y	N
yahB	Uncharacterized HTH-type transcriptional regulator	DSB, RF	Transcription regulation-DNA binding TF		6		Y
ybaO	Uncharacterized HTH-type transcriptional regulator	DSB	Transcription regulation-DNA binding TF		3		Y
ybbY	Unknown function- putative purine permease	DSB, RF	Unknown	SLC23A1, SLC23A2	6
yciT	Uncharacterized HTH-type transcriptional regulator	DSB, RF	Transcription regulation-DNA binding TF		3		Y
ydfU	Unknown function	DSB	Unknown		3	1.4
yhcM	Cell-division protein with ATPase activity	DSB	Various cellular processes-cell division	LACE1	3		Y
yhiM	Unknown function- inner membrane protein similarity	DSB, RF, AC, ROS	Unknown		3		Y	N
yihW	Uncharacterized HTH-type transcriptional regulator	DSB, AC	Transcription regulation-DNA binding TF		5		Y
yjjJ	Unknown function- putative kinase	DSB, AC, ROS	Unknown		3		Y
ykgA	Putative HTH-type transcriptional regulator	DSB, RF	Transcription regulation-DNA binding TF		3		Y
dam	DNA adenine methylase	RF	DNA replication		3		Y
dppD	Dipeptide transport ATP-binding protein	RF	Transporter-ABC transporter	ABCA1, ABCA10, ABCA12, ABCA13, ABCA2, ABCA3, ABCA4, ABCA5, ABCA6, ABCA7, ABCA8, ABCA9, ABCB1, ABCB10, ABCB11, ABCB4, ABCB5, ABCB6, ABCB7, ABCB8, ABCB9, ABCC1, ABCC10, ABCC11, ABCC12, ABCC2, ABCC4, ABCC5, ABCC8, ABCC9, ABCF1, ABCF2, ABCF3, ABCG1, ABCG2, ABCG4, ABCG5, ABCG8, CFTR, TAP1, TAP2	3		Y
dsbG	Thioldisulfide interchange protein	RF	oxidation reduction		3	1.1	Y
ftsX	Cell-division protein	RF, AC, ROS	Various cellular processes-cell division		3		Y	N
iap	Alkaline phosphatase isozyme conversion protein	RF	Various cellular processes		3		Y
mrr	Mrr restriction system protein	RF, AC, ROS	Various cellular processes-DNA endonuclease		3	95.0	Y
ORF6106.1	Unknown function	RF	Unknown		3	1.6
rplT	50S ribosomal protein L20	RF	Various cellular processes-protein biosynthesis	MRPL20	3		Y
sbcC	DNA endo-exonuclease SbcCD subunit C	RF, AC	DNA repair	SMC1A, SMC2	3		Y
smg	Unknown function	RF	Unknown		3
speA	Biosynthetic arginine decarboxylase	RF, ROS	Metabolism		6		Y
speC	Ornithine decarboxylase- constitutive	RF	Metabolism		3		Y
tas	Predicted oxidoreductase- NADP(H)-dependent aldo-keto reductase	RF, ROS	oxidation reduction	AKR1A1, AKR1B10, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1D1, AKR1E2, AKR7A2, AKR7A3, KCNAB1, KCNAB2, KCNAB3	3		Y	N
trpE	Anthranilate synthase component 1	RF	Metabolism		3
yafY	Unknown function- lipoprotein similarity	RF, AC, ROS	Unknown		3		Y	N
yddG	Unknown function- aromatic amino acid exporter similarity	RF	Unknown		3	8.1	Y
yhii	Unknown function- putative uncharacterized protein	RF	Unknown		3
ynfG	Unknown function- probable anaerobic dimethyl sulfoxide reductase chain	RF, AC, ROS	Unknown		3			N
ydfK	Unknown function	AC, ROS	Unknown		3			Y
yidP	Uncharacterized HTH-type transcriptional regulator	AC	Transcription regulation-DNA binding TF		3		Y
yihI	Der GTPase-activating protein	AC	Various cellular processes		3		Y
hemA	Glutamyl-tRNA reductase	ROS	oxidation reduction	CRYM	3		Y	Y
hns	DNA-binding protein H-NS	ROS, DSB, AC, H2O2	Transcription regulation-DNA binding TF		3		Y
zipA	Cell-division protein	ROS	Various cellular processes-cell division	TTN	3	12.3	Y	Y
ampG	AmpG muropeptide MFS transporter		Transporter	MFSD3, SLC33A1	3		Y
nikC	Nickel transport system permease protein		Transporter		3		Y
exoX	DNA 3?- single-strand Exonuclease 10 functions in mismatch repair		DNA repair		3		Y
hemG	Protoporphyrinogen IX dehydrogenase [menaquinone]		oxidation reduction		3		Y
hha	Hemolysin expression-modulating protein		Transcription regulation		3		Y
lepB	Signal peptidase I		Various cellular processes-protein biosynthesis	IMMP1L	3		Y
mdtB	Multidrug resistance protein		Transporter		3	2.9
mutM	Formamidopyrimidine-DNA glycosylase		DNA repair	NEIL1, NEIL2, NEIL3	3		Y
pdhR	Pyruvate dehydrogenase complex repressor		Metabolism		3		Y
pflF	Putative pyruvate formate lyase		Metabolism		3		Y
ppc	Phosphoenolpyruvate carboxylase		Metabolism		3
ptsN	Nitrogen regulatory protein		Metabolism		3		Y
setB	Sugar efflux transporter B		Transporter		3	3.6	Y
sfsA	Sugar fermentation stimulation protein A		Various cellular processes		3	11.6
waaN	myristoyl-acyl carrier protein (ACP)-dependent acyltransferase		Various cellular processes		3		Y
yehH	Putative molybdate metabolism regulator		Metabolism		3
yejH	Unknown function		Unknown	ERCC3, FANCM, IFIH1, RECQL	3
yijF	Unknown function		Unknown		3	1.8
dos	Oxygen sensor protein		Transcription regulation		6		Y

[PMID:24171103-1] Shee, C et al. (2013) Engineered proteins detect spontaneous DNA breakage in human and bacterial cells. Elife 2 e01222 PubMed OMPwiki page

[PMID:28090586-2] Xia, J et al. (2016) Holliday junction trap shows how cells use recombination and a junction-guardian role of RecQ helicase. Sci Adv 2 e1601605 PubMed OMPwiki page

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