OMP ST:71013 ! Escherichia coli K-12 BW25113 ftsA::SPA

Strain Summary

Strain Name	Escherichia coli K-12 BW25113 ftsA::SPA
Synonyms	ECK0095-C-FTSA-SPA-SPA (Nichols et al. 2011. Supplemental Table S2)
Taxon Information	Pangenome: Escherichia coli Subspecies and/or strain: K-12 NCBI Taxonomy ID: 83333
Genotype	DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 ftsA::SPA
Strain Reference	PMID:21185072
Strain availability
Ancestry	parent:OMP ST:800 ! Escherichia coli K-12 BW25113
Annotated phenotypes
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Phenotype Annotation

Annotation ID	Qualifier	OMP ID	OMP term name	Relative phenotype information	Experimental condition	ECO ID	ECO term name	Reference	Annotation Extension	Notes
OMP_AN:37263		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27594 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:SDS (CHEBI:8984) +EDTA (CHEBI:64758)	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:64758 + CHEBI:8984) SDS (CHEBI:8984) +EDTA (CHEBI:64758)	chemical concentration= 0.5%/0.5mM %/0.5mM normalized fitness= -4.52
OMP_AN:37264		OMP:0006036	decreased resistance to macrolide	Relative to: OMP_AN:27518 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Azithromycin	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:2955) Azithromycin	chemical concentration= 1 ug/ml normalized fitness= -3.26
OMP_AN:37265		OMP:0006045	increased resistance to beta-lactam compound	Relative to: OMP_AN:27535 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Cefsulodin sodium salt hydrate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:31380) Cefsulodin sodium salt hydrate	chemical concentration= 18 ug/ml normalized fitness= 3.04
OMP_AN:37266		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27514 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Chlorpromazine hydrochloride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:3649) Chlorpromazine hydrochloride	chemical concentration= 6 uM normalized fitness= -6.53
OMP_AN:37267		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27501 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Dibucaine	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:247956) Dibucaine	chemical concentration= 1.2 mM normalized fitness= -3.21
OMP_AN:37268		OMP:0006036	decreased resistance to macrolide	Relative to: OMP_AN:27520 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Erythromycin	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:42355) Erythromycin	chemical concentration= 0.1 ug/ml normalized fitness= -3.38
OMP_AN:37269		OMP:0007888	increased resistance to a metal	Relative to: OMP_AN:27580 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Nickel stress-Ni(II)Cl2 hexahydrate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:53542) Nickel stress-Ni(II)Cl2 hexahydrate	chemical concentration= 1 mM (LB) normalized fitness= 4.15
OMP_AN:37270		OMP:0007250	increased resistance to a chemical	Relative to: OMP_AN:27593 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:(-)-Norepinephrine	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:18357) (-)-Norepinephrine	chemical concentration= 1000 uM normalized fitness= 5.16
OMP_AN:37271		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27564 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Phleomycin	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:75044) Phleomycin	chemical concentration= 1 ug/ml normalized fitness= -3.57
OMP_AN:37272		OMP:0007074	increased growth factor requirement	Relative to: OMP_AN:27598 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:MOPS medium:Iron excess-FeSO4 heptahydride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:75836) Iron excess-FeSO4 heptahydride	chemical concentration= 1mM (MOPS; normal 100uM) normalized fitness= 3.73
OMP_AN:37273		OMP:0007888	increased resistance to a metal	Relative to: OMP_AN:27608 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:MOPS medium:Iron excess-FeSO4 heptahydride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:75836) Iron excess-FeSO4 heptahydride	chemical concentration= 1mM (MOPS; normal 100uM) normalized fitness= 3.73
OMP_AN:37274		OMP:0007074	increased growth factor requirement	Relative to: OMP_AN:27599 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:MOPS medium:Iron starvation-FeSO4·7H2O	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:75836) Iron starvation-FeSO4·7H2O	chemical concentration= 2uM (MOPS; normal 100uM) normalized fitness= 3.05
OMP_AN:37275		OMP:0007936	increased resistance to nutrient limitation	Relative to: OMP_AN:27609 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:MOPS medium:Iron starvation-FeSO4·7H2O	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:75836) Iron starvation-FeSO4·7H2O	chemical concentration= 2uM (MOPS; normal 100uM) normalized fitness= 3.05
OMP_AN:37276		OMP:0006040	decreased resistance to quinolone	Relative to: OMP_AN:27541 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Nalidixic acid sodium salt	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CID:3864541) Nalidixic acid sodium salt	chemical concentration= 2 ug/ml normalized fitness= -3.22
OMP_AN:37277		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27504 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Novobiocin sodium salt	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:31924) Novobiocin sodium salt	chemical concentration= 8 ug/ml normalized fitness= -3.34
OMP_AN:37278		OMP:0007011	increased population growth at alkaline pH	Relative to: OMP_AN:27623 Genotype differences: +lacZ4787(del)( +ftsA -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:TAPS	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (**SID:24900259) TAPS	chemical concentration= 10 normalized fitness= 3.31
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References

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