Category:ECO:0000238 ! Hi-C evidence

name: Hi-C evidence
def: "A type of chromosome conformation capture-based evidence that is derived by performing immunoprecipitation enrichment of ligated fragments events prior to product quantitation." [ECO:MCC]
is_a: ECO:0000232 ! chromosome conformation capture-based evidence
comment: Hi-C is used to study the structural properties and spatial organization of chromosomes inside cells. Hi-C is similar to other types of chromosome conformation capture technology, but involves the addition of biotinylated nucleotides during the second or fourth step and enrichment for ligated fragments using immunoprecipitation after the fourth step.