Category:ECO:0000239 ! chromosome conformation capture sequencing evidence

name:chromosome conformation capture sequencing evidence
def:"A type of chromosome conformation capture-based evidence that is derived by inverse polymerase chain reaction (inverse PCR) on a circularized 3C library prior to product quantitation with high-throughput (HT) sequencing." [ECO:MCC]
synonym:"3C sequencing" EXACT []
synonym:"3C-seq" EXACT []
synonym:"4C sequencing" EXACT []
synonym:"4C-seq" EXACT []
synonym:"circularized 3C sequencing" EXACT []
synonym:"circularized 3C-seq" EXACT []
is_a:ECO:0000232 ! chromosome conformation capture-based evidence
comment:3C-seq is used to study the structural properties and spatial organization of chromosomes inside cells. Like other types of chromosome conformation capture technology, 3C-seq differs only in the fifth step, which involves inverse polymerase chain reaction (PCR) on a circularized 3C library prior to product quantitation.