OMP ST:926 ! Escherichia coli K-12 JW5248

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Strain Summary

Strain Name

Escherichia_coli_K-12_JW5248

Synonyms

BW25113 marR751(del)::kan, ECK1523

Taxon Information
  • Pangenome: Escherichia coli
  • Subspecies and/or strain: K-12
  • NCBI Taxonomy ID: 83333
Genotype

DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 marR751(del)::kan

Strain Reference
Strain availability

CGSC

Ancestry

parent:OMP ST:800 ! Escherichia coli K-12 BW25113

Annotated phenotypes


edit table


Notes

Phenotype Annotation

Annotation ID Qualifier OMP ID OMP term name Relative phenotype information Experimental condition ECO ID ECO term name Reference Annotation Extension Notes

OMP_AN:666

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:665

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:mecillinam (0.12 ug ml-1)

PMID:21185072[2]

CHEBI:51208 mecillinam

fitness score = 6.61

OMP_AN:667

OMP:0006068

increased resistance to chloramphenicol

Relative to: OMP_AN:649

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:chloramphenicol (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:17698 chloramphenicol

fitness score = 5.13

OMP_AN:669

OMP:0006063

increased resistance to tetracycline

Relative to: OMP_AN:668

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:minocycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50694 minocycline

fitness score = 4.89

OMP_AN:671

OMP:0000334

increased resistance to aminopyrimidine

Relative to: OMP_AN:670

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:trimethoprim (0.2 ug ml-1)

PMID:21185072[2]

CHEBI:45924 trimethoprim

fitness score = 4.46

OMP_AN:672

OMP:0006063

increased resistance to tetracycline

Relative to: OMP_AN:647

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:tetracycline (1 ug ml-1)

PMID:21185072[2]

CHEBI:27902 tetracycline

fitness score = 4.22

OMP_AN:673

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:653

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:streptonigrin (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:9287 streptonigrin

fitness score = 4.09

OMP_AN:675

OMP:0006063

increased resistance to tetracycline

Relative to: OMP_AN:870

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxycycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50845 doxycycline

fitness score = 4.03

OMP_AN:676

OMP:0007384

increased resistance to a benzamide

Relative to: OMP_AN:659

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:CHIR-090 (0.075 ug ml-1)

PMID:21185072[2]

PubChem CID:11546620 Chir-090

fitness score = 3.93

OMP_AN:678

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:677

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:ciprofloxacin (0.004 ug ml-1)

PMID:21185072[2]

CHEBI:100241 ciprofloxacin

fitness score = 3.70

OMP_AN:680

OMP:0007171

resistant to antimicrobial peptide

Relative to: OMP_AN:679

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:bleomycin (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:22907 bleomycin

fitness score = 3.50

OMP_AN:682

OMP:0006037

increased resistance to macrolide

Relative to: OMP_AN:681

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:azithromycin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:2955 azithromycin

fitness score = 3.30

OMP_AN:684

OMP:0006037

increased resistance to macrolide

Relative to: OMP_AN:683

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:erythromycin (5.0 ug ml-1)

PMID:21185072[2]

CHEBI:48923 erythromycin

fitness score = 3.29

OMP_AN:686

OMP:0007376

increased resistance to alkylating agent

Relative to: OMP_AN:685

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:MMS (0.05%)

PMID:21185072[2]

CHEBI:25255 MMS

fitness score = 8.56

OMP_AN:688

OMP:0007362

Increased resistance to a nucleoside

Relative to: OMP_AN:687

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:azidothymidine (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:10110 azidothymidine

fitness score = 3.73

OMP_AN:690

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:689

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:propidium iodide (50 ug ml-1)

PMID:21185072[2]

CHEBI:51240 propidium iodide

fitness score = 5.15

OMP_AN:698

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:697

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:cefoxitin (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:209807 cefoxitin

fitness score = -3.14

OMP_AN:700

OMP:0007219

decreased resistance to rifamycin

Relative to: OMP_AN:699

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:rifampicin (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:28077 rifampicin

fitness score = -3.29

OMP_AN:816

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:815

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:A22 (15 ug ml-1)

PMID:21185072[2]

CID:16741200 A22

fitness score = -3.78

OMP_AN:819

OMO:0005345

Relative to: OMP_AN:817

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:procaine (30 ug ml-1)

PMID:21185072[2]

CHEBI:8430 procaine

fitness score = -3.39

OMP_AN:831

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:827

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:ethanol (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:16236 ethanol

fitness score = -3.78

OMP_AN:832

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:828

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:bile 0.5%

PMID:21185072[2]

CHEBI:22868 bile

fitness score = -3.51

OMP_AN:833

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:829

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:glycerol

PMID:21185072[2]

CHEBI:17754 glycerol

fitness score = -3.45

OMP_AN:834

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:830

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:maltose

PMID:21185072[2]

CHEBI:17306 maltose

fitness score = -3.05

OMP_AN:7514

OMP:0005347

Relative to: OMP_AN:7500

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:triclosan (0.05 ug ml-1)

PMID:21185072[2]

CHEBI:164200 triclosan

fitness score = 4.25

OMP_AN:7562

OMP:0005347

increased resistance to organic aromatic compounds

Relative to: OMP_AN:7495

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

medium:benzalkonium (25 ug ml-!)

PMID:21185072[2]

CHEBI:3020 benzalkonium

fitness score = 3.09

OMP_AN:35883

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27552

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Azidothymidine
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:10110) Azidothymidine

  • chemical concentration= 1 ng/ml
  • normalized fitness= 3.73

OMP_AN:35884

OMP:0006037

increased resistance to macrolide

Relative to: OMP_AN:27518

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Azithromycin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:2955) Azithromycin

  • chemical concentration= 1 ug/ml
  • normalized fitness= 3.3

OMP_AN:35885

OMP:0007895

increased resistance to a surfactant

Relative to: OMP_AN:27581

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Benzalkonium chloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:3020) Benzalkonium chloride

  • chemical concentration= 25 ug/ml
  • normalized fitness= 3.09

OMP_AN:35886

OMP:0007903

decreased resistance to bile acids

Relative to: OMP_AN:27587

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Bile salts chemical-Mixture of sodium cholate (CHEBI:26711) and sodium deoxycholate (CHEBI:9177)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:26711 + CHEBI:9177) Bile salts chemical-Mixture of sodium cholate (CHEBI:26711) and sodium deoxycholate (CHEBI:9177)

  • chemical concentration= 0.5 %
  • normalized fitness= -3.51

OMP_AN:35887

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27561

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Bleomycin sulfate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:34582) Bleomycin sulfate

  • chemical concentration= 0.5 ug/ml
  • normalized fitness= 3.5

OMP_AN:35888

OMP:0007075

decreased growth factor requirement

Relative to: OMP_AN:27604

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:M9
  • medium:Glycerol
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:17754) Glycerol

  • chemical concentration= 0.4%
  • normalized fitness= -3.45

OMP_AN:35889

OMP:0007070

decreased organic carbon source utilization

Relative to: OMP_AN:27614

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:M9
  • medium:Glycerol
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:17754) Glycerol

  • chemical concentration= 0.4%
  • normalized fitness= -3.45

OMP_AN:35890

OMP:0007376

increased resistance to an alkylating agent

Relative to: OMP_AN:27502

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:methyl methanesulfonate (MMS)
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:25255) methyl methanesulfonate (MMS)

  • chemical concentration= 0.05%
  • normalized fitness= 8.56

OMP_AN:35891

OMP:0007075

decreased growth factor requirement

Relative to: OMP_AN:27605

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:M9
  • medium:D-(+) Maltose monohydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:23615261) D-(+) Maltose monohydrate

  • chemical concentration= 0.1%
  • normalized fitness= -3.05

OMP_AN:35892

OMP:0007070

decreased organic carbon source utilization

Relative to: OMP_AN:27615

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:M9
  • medium:D-(+) Maltose monohydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:23615261) D-(+) Maltose monohydrate

  • chemical concentration= 0.1%
  • normalized fitness= -3.05

OMP_AN:35893

OMP:0007250

increased resistance to a chemical

Relative to: OMP_AN:27570

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Propidium iodide
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:51240) Propidium iodide

  • chemical concentration= 50 ug/ml
  • normalized fitness= 5.15

OMP_AN:35894

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:27543

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Streptonigrin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:9287) Streptonigrin

  • chemical concentration= 0.5 ug/ml
  • normalized fitness= 4.09

OMP_AN:35895

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27588

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Triclosan/Irgasan
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:164200) Triclosan/Irgasan

  • chemical concentration= 0.05 ug/ml
  • normalized fitness= 4.25

OMP_AN:35896

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:27539

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Ciprofloxacin hydrochloride hydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:59936) Ciprofloxacin hydrochloride hydrate

  • chemical concentration= 0.004 ug/ml
  • normalized fitness= 3.7

OMP_AN:35897

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27569

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:EtOH
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:16236) EtOH

  • chemical concentration= 2 %
  • normalized fitness= -3.78

OMP_AN:35898

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27500

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Trimethoprim
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:45924) Trimethoprim

  • chemical concentration= 0.2 ug/ml
  • normalized fitness= 4.46

OMP_AN:35899

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27591

Genotype differences:

+lacZ4787(del)( +marR751(del) -lacZ4787(del)

Condition differences:

no differences

ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:45924 + CHEBI:9331) Trimethoprim (CHEBI:45924) + Sulfamethizole (CHEBI:9331)

  • chemical concentration= 0.1 + 50 ug/ml
  • normalized fitness= -4.1
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Additional Information

Links

References

See Help:References for how to manage references in OMPwiki.

  1. ↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 Nichols, RJ et al. (2011) Phenotypic landscape of a bacterial cell. Cell 144 143-56 PubMed
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