OMP ST:1214 ! Escherichia coli K-12 JW0451

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Strain Summary

Strain Name

Escherichia coli K-12 JW0451

Synonyms

BW25113 acrB747(del)::kan, ECK0456

Taxon Information
  • Pangenome: Escherichia coli
  • Subspecies and/or strain: K-12
  • NCBI Taxonomy ID: 83333
Genotype

DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 acrB747(del)::kan

Strain Reference
Strain availability

CGSC

Ancestry

parent:OMP ST:800 ! Escherichia coli K-12 BW25113

Annotated phenotypes


edit table


Notes

Phenotype Annotation

Annotation ID Qualifier OMP ID OMP term name Relative phenotype information Experimental condition ECO ID ECO term name Reference Annotation Extension Notes

OMP_AN:1098

OMP:0005347

Relative to: OMP_AN:817

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:procaine (30 ug ml-1)

PMID:21185072[2]

CHEBI:8430 procaine

fitness score = 7.16

OMP_AN:1100

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:1099

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:EGTA (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:30740 EGTA

fitness score = 3.83

OMP_AN:1102

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:1101

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:polymixin B (6.0 ug ml-1)

PMID:21185072[2]

CHEBI:8309 polymixin B

fitness score = 4.02

OMP_AN:1104

OMP:0007174

increased resistance to antimicrobial peptide

Relative to: OMP_AN:1103

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:vancomycin (10 ug ml-1)

PMID:21185072[2]

CHEBI:28001 vancomycin

fitness score = 3.80

OMP_AN:1105

OMP:0006041

increased resistance to quinolone

Relative to: OMP_AN:703

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxorubicin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:28748 doxorubicin

fitness score = 3.70

OMP_AN:1107

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:1106

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:cholate 0.1%

PMID:21185072[2]

CHEBI:29747 cholate

fitness score = 3.67

OMP_AN:1109

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:1108

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:amoxicillin (1.5 ug ml-1)

PMID:21185072[2]

CHEBI:2676 amoxicillin

itness score = 3.56

OMP_AN:1111

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:1110

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:ampicillin (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:28971 ampicillin

fitness score = 3.28

OMP_AN:1113

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:1112

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:aztreonam (0.002 ug ml-1)

PMID:21185072[2]

CHEBI:161680 aztreonam

fitness score = 3.16

OMP_AN:1115

OMP:0005097

increased resistance to UV radiation

Relative to: OMP_AN:1114

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:UV (24 seconds)

PMID:21185072[2]

fitness score = 3.20

OMP_AN:1117

OMP:0007249

Increased sensitivity to a chemical

Relative to: OMP_AN:1116

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:ethanol (6.0 ug ml-1)

PMID:21185072[2]

CHEBI:16236 ethanol

fitness score = 3.05

OMP_AN:1130

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:841

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:dibucaine (1.2 ug ml-1)

PMID:21185072[2]

CHEBI:247956 dibucaine

fitness score = -26.92

OMP_AN:1162

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:689

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:propidium iodide (50 ug ml-1)

PMID:21185072[2]

CHEBI:51240 propidium iodide

fitness score = -23.56

OMP_AN:1163

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:822

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:novobiocin (30 ug ml-1)

PMID:21185072[2]

CHEBI:28368 novobiocin

fitness score = -26.29

OMP_AN:1164

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:849

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:oxacillin (40 ug ml-1)

PMID:21185072[2]

CHEBI:7809 oxacillin

fitness score = -25.93

OMP_AN:1165

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:855

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:mitomycinc (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:27504 mitomycinc

fitness score = -24.34

OMP_AN:1166

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:835

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:ethidium bromide (50 ug ml-1)

PMID:21185072[2]

CHEBI:4883 ethidium bromide

fitness score = -22.13

OMP_AN:1167

OMP:0006067

decreased resistance to chloramphenicol

Relative to: OMP_AN:649

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:chloramphenicol (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:17698 chloramphenicol

fitness score = -16.67

OMP_AN:1168

OMP:0007385

decreased resistance benzamides

Relative to: OMP_AN:659

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:CHIR-090 (0.075 ug ml-1)

PMID:21185072[2]

PubChem CID:11546620 Chir-090

fitness score = -10.62

OMP_AN:1169

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:872

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:erythromycin (10.0 ug ml-1)

PMID:21185072[2]

CHEBI:48923 erythromycin

fitness score = -20.89

OMP_AN:1170

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:845

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:deoxycholate 2.0%

PMID:21185072[2]

CHEBI:23614 deoxycholate

fitness score = -20.88

OMP_AN:1171

OMP:0000335

decreased resistance to aminopyrimidine

Relative to: OMP_AN:853

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:trimethoprim (0.4 ug ml-1)

PMID:21185072[2]

CHEBI:45924 trimethoprim

fitness score = -11.04

OMP_AN:1172

OMP:0007363

decreased resistance to a nucleoside

Relative to: OMP_AN:657

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:puromycin (25 ug ml-1)

PMID:21185072[2]

CHEBI:17939 puromycin

fitness score = -20.05

OMP_AN:1173

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:868

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:fusidic acid (50 ug ml-1)

PMID:21185072[2]

CHEBI:29013 fusidicacid

fitness score = -18.70

OMP_AN:1174

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:859

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:clarythromycin (10.0 ug ml-1)

PMID:21185072[2]

CID: 84029 clarythromycin

fitness score = -19.37

OMP_AN:1230

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:668

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:minocycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50694 minocycline

fitness score = -13.86

OMP_AN:1231

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:863

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:spiramycin (20 ug ml-1)

PMID:21185072[2]

CHEBI:85260 spiramycin

fitness score = -18.68

OMP_AN:1232

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:843

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxorubicin (10 ug ml-1)

PMID:21185072[2]

CHEBI:28748 doxorubicin

fitness score = -17.37

OMP_AN:1234

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:870

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:doxycycline (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:50845 doxycycline

fitness score = -9.99

OMP_AN:1323

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:653

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:streptonigrin (0.5 ug ml-1)

PMID:21185072[2]

CHEBI:9287 streptonigrin

fitness score = -16.75

OMP_AN:1325

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:1324

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:PMS (0.1 ug ml-1)

PMID:21185072[2]

CHEBI:53396 PMS

fitness score = -15.93

OMP_AN:1326

OMP:0007370

decreased resistance to an acridine

Relative to: OMP_AN:663

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:acriflavine (10 ug ml-1)

PMID:21185072[2]

CHEBI:74728 acriflavinium chloride

fitness score = -16.66

OMP_AN:1327

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:894

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:verapamil (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:9948 verapamil

fitness score = -3.30

OMP_AN:1328

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:851

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:cholate 2.0%

PMID:21185072[2]

CHEBI:29747 cholate

fitness score = -15.87

OMP_AN:1332

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:1331

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:nalidixic acid (2.0 ug ml-1)

PMID:21185072[2]

CHEBI:100147 nalidixic acid

fitness score = -12.17

OMP_AN:1333

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:661

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:mecillinam (0.09 ug ml-1)

PMID:21185072[2]

CHEBI:51208 mecillinam

fitness score = -10.45

OMP_AN:1335

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:1334

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:ampicillin (8.0 ug ml-1)

PMID:21185072[2]

CHEBI:28971 ampicillin

fitness score = -10.32

OMP_AN:1336

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:861

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:bile 2.0%

PMID:21185072[2]

CHEBI:22868 bile

fitness score = -12.10

OMP_AN:1338

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:1337

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:pyocyanin (10.0 ug ml-1)

PMID:21185072[2]

CHEBI:62220 pyocyanin

fitness score = -11.92

OMP_AN:1340

OMP:0006061

decreased resistance to tetracycline

Relative to: OMP_AN:1339

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:tetracycline (0.75 ug ml-1)

PMID:21185072[2]

CHEBI:35006 tetracycline hydrochloride

fitness score = -8.81

OMP_AN:1341

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:847

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:SDS 4.0%

PMID:21185072[2]

CHEBI:8984 SDS

fitness score = -8.31

OMP_AN:1343

OMP:0006040

decreased resistance to quinolone

Relative to: OMP_AN:1342

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:ciprofloxacin (0.006 ug ml-1)

PMID:21185072[2]

CHEBI:100241 ciprofloxacin

fitness score = -3.43

OMP_AN:1345

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:1344

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:spectinomycin (4.0 ug ml-1)

PMID:21185072[2]

CHEBI:9215 spectinomycin

fitness score = -7.66

OMP_AN:1347

OMP:0007173

decreased resistance to antimicrobial peptide

Relative to: OMP_AN:1346

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:bleomycin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:22907 bleomycin

fitness score = -3.66

OMP_AN:1348

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:681

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:azithromycin (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:2955 azithromycin

fitness score = -6.36

OMP_AN:1349

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:857

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:taurocholate 1.0%

PMID:21185072[2]

CHEBI:36257 taurocholate

fitness score = -5.94

OMP_AN:1351

OMP:0007363

decreased resistance to a nucleoside

Relative to: OMP_AN:1350

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:azidothymidine (2.5 ug ml-1)

PMID:21185072[2]

CHEBI:10110 azidothymidine

fitness score = -4.31

OMP_AN:1352

OMP:0005276

decreased resistance to organic heterocyclic compound

Relative to: OMP_AN:885

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:chloropromazine (24 ug ml-1)

PMID:21185072[2]

CHEBI:3647 chloropromazine

fitness score = -4.22

OMP_AN:1391

OMP:0007250

decreased sensitivity to a chemical

Relative to: OMP_AN:1390

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:peroxide (1.0 ug ml-1)

PMID:21185072[2]

CHEBI:44785 peroxide



fitness score = 3.17

OMP_AN:1392

OMP:0007377

decreased resistance to alkylating agent

Relative to: OMP_AN:685

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:MMS (0.05%)

PMID:21185072[2]

CHEBI:25255 MMS

fitness score = 3.18

OMP_AN:1395

OMP:0007500

decreased resistance to an epoxide

Relative to: OMP_AN:1393

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

medium:cerulenin (6.0 ug ml-1)

PMID:21185072[2]

CHEBI:171741 cerulenin

fitness score = -12.35

OMP_AN:28508

OMP:0006045

increased resistance to beta-lactam compound

Relative to: OMP_AN:27530

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Amoxicillin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:2676) Amoxicillin

  • chemical concentration= 1.5 ug/ml
  • normalized fitness= 3.56

OMP_AN:28509

OMP:0006044

decreased resistance to beta-lactam

Relative to: OMP_AN:27531

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Ampicillin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:28971) Ampicillin

  • chemical concentration= 8 ug/ml
  • normalized fitness= -10.32

OMP_AN:28510

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27552

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Azidothymidine
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:10110) Azidothymidine

  • chemical concentration= 2.5 ng/ml
  • normalized fitness= -4.31

OMP_AN:28511

OMP:0006036

decreased resistance to macrolide

Relative to: OMP_AN:27518

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Azithromycin
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:2955) Azithromycin

  • chemical concentration= 1 ug/ml
  • normalized fitness= -6.36

OMP_AN:28512

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27514

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Chlorpromazine hydrochloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:3649) Chlorpromazine hydrochloride

  • chemical concentration= 6 uM
  • normalized fitness= -4.22

OMP_AN:28513

OMP:0007902

increased resistance to bile acids

Relative to: OMP_AN:27585

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Cholate sodium hydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:23679061) Cholate sodium hydrate

  • chemical concentration= 0.1 %
  • normalized fitness= 3.67

OMP_AN:28514

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27506

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Doxorubicin hydrochloride
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:31522) Doxorubicin hydrochloride

  • chemical concentration= 10 ug/ml
  • normalized fitness= -17.37

OMP_AN:28515

OMP:0007249

decreased resistance to a chemical

Relative to: OMP_AN:27510

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Mitomycin C
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:27504) Mitomycin C

  • chemical concentration= 0.1 ug/ml
  • normalized fitness= -24.34

OMP_AN:28516

OMP:0007903

decreased resistance to bile acids

Relative to: OMP_AN:27584

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Taurocholic acid sodium salt hydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CID:23687511) Taurocholic acid sodium salt hydrate

  • chemical concentration= 1 %
  • normalized fitness= -5.94

OMP_AN:28517

OMP:0007879

decreased resistance to an antimicrobial agent

Relative to: OMP_AN:27588

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Triclosan/Irgasan
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:164200) Triclosan/Irgasan

  • chemical concentration= 0.05 ug/ml
  • normalized fitness= -14.74

OMP_AN:28518

OMP:0007878

increased resistance to an antimicrobial agent

Relative to: OMP_AN:27566

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:Vancomycin HCl hydrate
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:9932) Vancomycin HCl hydrate

  • chemical concentration= 10 ug/ml
  • normalized fitness= 3.8

OMP_AN:28519

OMP:0007250

increased resistance to a chemical

Relative to: OMP_AN:27569

Genotype differences:

+lacZ4787(del)( +acrB747(del) -lacZ4787(del)

Condition differences:

no differences

  • temperature:37C
  • medium:LB agar
  • medium:EtOH
 ECO:0007005

high throughput direct assay evidence used in manual assertion

PMID:21185072[2]

towards some (CHEBI:16236) EtOH

  • chemical concentration= 6 %
  • normalized fitness= 3.05
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References

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  1. ↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed
  2. ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 2.52 2.53 2.54 2.55 2.56 2.57 2.58 2.59 2.60 2.61 2.62 Nichols, RJ et al. (2011) Phenotypic landscape of a bacterial cell. Cell 144 143-56 PubMed
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