OMP ST:1214 ! Escherichia coli K-12 JW0451
Contents
Strain Summary
| Strain Name |
Escherichia coli K-12 JW0451 |
|---|---|
| Synonyms |
BW25113 acrB747(del)::kan, ECK0456 |
| Taxon Information |
|
| Genotype |
DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 acrB747(del)::kan |
| Strain Reference |
|
| Strain availability | |
| Ancestry | |
| Annotated phenotypes |
|
Notes
Phenotype Annotation
| Annotation ID | Qualifier | OMP ID | OMP term name | Relative phenotype information | Experimental condition | ECO ID | ECO term name | Reference | Annotation Extension | Notes |
|---|---|---|---|---|---|---|---|---|---|---|
|
OMP_AN:1098 |
OMP:0005347 |
Relative to: OMP_AN:817 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:procaine (30 ug ml-1) |
CHEBI:8430 procaine |
fitness score = 7.16 | |||||
|
OMP_AN:1100 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:1099 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:EGTA (2.0 ug ml-1) |
CHEBI:30740 EGTA |
fitness score = 3.83 | ||||
|
OMP_AN:1102 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:1101 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:polymixin B (6.0 ug ml-1) |
CHEBI:8309 polymixin B |
fitness score = 4.02 | ||||
|
OMP_AN:1104 |
OMP:0007174 |
increased resistance to antimicrobial peptide |
Relative to: OMP_AN:1103 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:vancomycin (10 ug ml-1) |
CHEBI:28001 vancomycin |
fitness score = 3.80 | ||||
|
OMP_AN:1105 |
OMP:0006041 |
increased resistance to quinolone |
Relative to: OMP_AN:703 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:doxorubicin (1.0 ug ml-1) |
CHEBI:28748 doxorubicin |
fitness score = 3.70 | ||||
|
OMP_AN:1107 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:1106 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:cholate 0.1% |
CHEBI:29747 cholate |
fitness score = 3.67 | ||||
|
OMP_AN:1109 |
OMP:0006045 |
increased resistance to beta-lactam compound |
Relative to: OMP_AN:1108 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:amoxicillin (1.5 ug ml-1) |
CHEBI:2676 amoxicillin |
itness score = 3.56 | ||||
|
OMP_AN:1111 |
OMP:0006045 |
increased resistance to beta-lactam compound |
Relative to: OMP_AN:1110 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:ampicillin (2.0 ug ml-1) |
CHEBI:28971 ampicillin |
fitness score = 3.28 | ||||
|
OMP_AN:1113 |
OMP:0006045 |
increased resistance to beta-lactam compound |
Relative to: OMP_AN:1112 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:aztreonam (0.002 ug ml-1) |
CHEBI:161680 aztreonam |
fitness score = 3.16 | ||||
|
OMP_AN:1115 |
OMP:0005097 |
increased resistance to UV radiation |
Relative to: OMP_AN:1114 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:UV (24 seconds) |
fitness score = 3.20 | |||||
|
OMP_AN:1117 |
OMP:0007249 |
Increased sensitivity to a chemical |
Relative to: OMP_AN:1116 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:ethanol (6.0 ug ml-1) |
CHEBI:16236 ethanol |
fitness score = 3.05 | ||||
|
OMP_AN:1130 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:841 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:dibucaine (1.2 ug ml-1) |
CHEBI:247956 dibucaine |
fitness score = -26.92 | ||||
|
OMP_AN:1162 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:689 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:propidium iodide (50 ug ml-1) |
CHEBI:51240 propidium iodide |
fitness score = -23.56 | ||||
|
OMP_AN:1163 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:822 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:novobiocin (30 ug ml-1) |
CHEBI:28368 novobiocin |
fitness score = -26.29 | ||||
|
OMP_AN:1164 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:849 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:oxacillin (40 ug ml-1) |
CHEBI:7809 oxacillin |
fitness score = -25.93 | ||||
|
OMP_AN:1165 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:855 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:mitomycinc (0.1 ug ml-1) |
CHEBI:27504 mitomycinc |
fitness score = -24.34 | ||||
|
OMP_AN:1166 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:835 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:ethidium bromide (50 ug ml-1) |
CHEBI:4883 ethidium bromide |
fitness score = -22.13 | ||||
|
OMP_AN:1167 |
OMP:0006067 |
decreased resistance to chloramphenicol |
Relative to: OMP_AN:649 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:chloramphenicol (2.0 ug ml-1) |
CHEBI:17698 chloramphenicol |
fitness score = -16.67 | ||||
|
OMP_AN:1168 |
OMP:0007385 |
decreased resistance benzamides |
Relative to: OMP_AN:659 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:CHIR-090 (0.075 ug ml-1) |
PubChem CID:11546620 Chir-090 |
fitness score = -10.62 | ||||
|
OMP_AN:1169 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:872 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:erythromycin (10.0 ug ml-1) |
CHEBI:48923 erythromycin |
fitness score = -20.89 | ||||
|
OMP_AN:1170 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:845 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:deoxycholate 2.0% |
CHEBI:23614 deoxycholate |
fitness score = -20.88 | ||||
|
OMP_AN:1171 |
OMP:0000335 |
decreased resistance to aminopyrimidine |
Relative to: OMP_AN:853 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:trimethoprim (0.4 ug ml-1) |
CHEBI:45924 trimethoprim |
fitness score = -11.04 | ||||
|
OMP_AN:1172 |
OMP:0007363 |
decreased resistance to a nucleoside |
Relative to: OMP_AN:657 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:puromycin (25 ug ml-1) |
CHEBI:17939 puromycin |
fitness score = -20.05 | ||||
|
OMP_AN:1173 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:868 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:fusidic acid (50 ug ml-1) |
CHEBI:29013 fusidicacid |
fitness score = -18.70 | ||||
|
OMP_AN:1174 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:859 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:clarythromycin (10.0 ug ml-1) |
CID: 84029 clarythromycin |
fitness score = -19.37 | ||||
|
OMP_AN:1230 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:668 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:minocycline (1.0 ug ml-1) |
CHEBI:50694 minocycline |
fitness score = -13.86 | ||||
|
OMP_AN:1231 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:863 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:spiramycin (20 ug ml-1) |
CHEBI:85260 spiramycin |
fitness score = -18.68 | ||||
|
OMP_AN:1232 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:843 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:doxorubicin (10 ug ml-1) |
CHEBI:28748 doxorubicin |
fitness score = -17.37 | ||||
|
OMP_AN:1234 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:870 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:doxycycline (1.0 ug ml-1) |
CHEBI:50845 doxycycline |
fitness score = -9.99 | ||||
|
OMP_AN:1323 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:653 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:streptonigrin (0.5 ug ml-1) |
CHEBI:9287 streptonigrin |
fitness score = -16.75 | ||||
|
OMP_AN:1325 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:1324 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:PMS (0.1 ug ml-1) |
CHEBI:53396 PMS |
fitness score = -15.93 | ||||
|
OMP_AN:1326 |
OMP:0007370 |
decreased resistance to an acridine |
Relative to: OMP_AN:663 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:acriflavine (10 ug ml-1) |
CHEBI:74728 acriflavinium chloride |
fitness score = -16.66 | ||||
|
OMP_AN:1327 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:894 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:verapamil (1.0 ug ml-1) |
CHEBI:9948 verapamil |
fitness score = -3.30 | ||||
|
OMP_AN:1328 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:851 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:cholate 2.0% |
CHEBI:29747 cholate |
fitness score = -15.87 | ||||
|
OMP_AN:1332 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:1331 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:nalidixic acid (2.0 ug ml-1) |
CHEBI:100147 nalidixic acid |
fitness score = -12.17 | ||||
|
OMP_AN:1333 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:661 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:mecillinam (0.09 ug ml-1) |
CHEBI:51208 mecillinam |
fitness score = -10.45 | ||||
|
OMP_AN:1335 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:1334 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:ampicillin (8.0 ug ml-1) |
CHEBI:28971 ampicillin |
fitness score = -10.32 | ||||
|
OMP_AN:1336 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:861 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:bile 2.0% |
CHEBI:22868 bile |
fitness score = -12.10 | ||||
|
OMP_AN:1338 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:1337 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:pyocyanin (10.0 ug ml-1) |
CHEBI:62220 pyocyanin |
fitness score = -11.92 | ||||
|
OMP_AN:1340 |
OMP:0006061 |
decreased resistance to tetracycline |
Relative to: OMP_AN:1339 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:tetracycline (0.75 ug ml-1) |
CHEBI:35006 tetracycline hydrochloride |
fitness score = -8.81 | ||||
|
OMP_AN:1341 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:847 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:SDS 4.0% |
CHEBI:8984 SDS |
fitness score = -8.31 | ||||
|
OMP_AN:1343 |
OMP:0006040 |
decreased resistance to quinolone |
Relative to: OMP_AN:1342 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:ciprofloxacin (0.006 ug ml-1) |
CHEBI:100241 ciprofloxacin |
fitness score = -3.43 | ||||
|
OMP_AN:1345 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:1344 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:spectinomycin (4.0 ug ml-1) |
CHEBI:9215 spectinomycin |
fitness score = -7.66 | ||||
|
OMP_AN:1347 |
OMP:0007173 |
decreased resistance to antimicrobial peptide |
Relative to: OMP_AN:1346 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:bleomycin (1.0 ug ml-1) |
CHEBI:22907 bleomycin |
fitness score = -3.66 | ||||
|
OMP_AN:1348 |
OMP:0006036 |
decreased resistance to macrolide |
Relative to: OMP_AN:681 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:azithromycin (1.0 ug ml-1) |
CHEBI:2955 azithromycin |
fitness score = -6.36 | ||||
|
OMP_AN:1349 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:857 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:taurocholate 1.0% |
CHEBI:36257 taurocholate |
fitness score = -5.94 | ||||
|
OMP_AN:1351 |
OMP:0007363 |
decreased resistance to a nucleoside |
Relative to: OMP_AN:1350 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:azidothymidine (2.5 ug ml-1) |
CHEBI:10110 azidothymidine |
fitness score = -4.31 | ||||
|
OMP_AN:1352 |
OMP:0005276 |
decreased resistance to organic heterocyclic compound |
Relative to: OMP_AN:885 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:chloropromazine (24 ug ml-1) |
CHEBI:3647 chloropromazine |
fitness score = -4.22 | ||||
|
OMP_AN:1391 |
OMP:0007250 |
decreased sensitivity to a chemical |
Relative to: OMP_AN:1390 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:peroxide (1.0 ug ml-1) |
CHEBI:44785 peroxide
|
fitness score = 3.17 | ||||
|
OMP_AN:1392 |
OMP:0007377 |
decreased resistance to alkylating agent |
Relative to: OMP_AN:685 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:MMS (0.05%) |
CHEBI:25255 MMS |
fitness score = 3.18 | ||||
|
OMP_AN:1395 |
OMP:0007500 |
decreased resistance to an epoxide |
Relative to: OMP_AN:1393 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
medium:cerulenin (6.0 ug ml-1) |
CHEBI:171741 cerulenin |
fitness score = -12.35 | ||||
|
OMP_AN:28508 |
OMP:0006045 |
increased resistance to beta-lactam compound |
Relative to: OMP_AN:27530 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
|
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
towards some (CHEBI:2676) Amoxicillin |
| ||
|
OMP_AN:28509 |
OMP:0006044 |
decreased resistance to beta-lactam |
Relative to: OMP_AN:27531 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
|
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
towards some (CHEBI:28971) Ampicillin |
| ||
|
OMP_AN:28510 |
OMP:0007879 |
decreased resistance to an antimicrobial agent |
Relative to: OMP_AN:27552 Genotype differences: +lacZ4787(del)( +acrB747(del) -lacZ4787(del) Condition differences: no differences |
|
ECO:0007005 |
high throughput direct assay evidence used in manual assertion |
towards some (CHEBI:10110) Azidothymidine |
| ||
Additional Information
Links
References
See Help:References for how to manage references in OMPwiki.
- ↑ Baba, T et al. (2006) Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection. Mol. Syst. Biol. 2 2006.0008 PubMed OMPwiki page
- ↑ 2.00 2.01 2.02 2.03 2.04 2.05 2.06 2.07 2.08 2.09 2.10 2.11 2.12 2.13 2.14 2.15 2.16 2.17 2.18 2.19 2.20 2.21 2.22 2.23 2.24 2.25 2.26 2.27 2.28 2.29 2.30 2.31 2.32 2.33 2.34 2.35 2.36 2.37 2.38 2.39 2.40 2.41 2.42 2.43 2.44 2.45 2.46 2.47 2.48 2.49 2.50 2.51 2.52 2.53 Nichols, RJ et al. (2011) Phenotypic landscape of a bacterial cell. Cell 144 143-56 PubMed OMPwiki page
o
- OMP:0000335 ! decreased resistance to aminopyrimidine
- OMP:0005097 ! increased resistance to UV radiation
- OMP:0005276 ! decreased resistance to organic heterocyclic compound
- OMP:0005347 ! increased resistance to organic aromatic compounds
- OMP:0006036 ! decreased resistance to macrolide
- OMP:0006040 ! decreased resistance to quinolone
- OMP:0006041 ! increased resistance to quinolone
- OMP:0006044 ! decreased resistance to beta-lactam
- OMP:0006045 ! increased resistance to beta-lactam compound
- OMP:0006061 ! decreased resistance to tetracycline
- OMP:0006067 ! decreased resistance to chloramphenicol
- OMP:0007173 ! decreased resistance to antimicrobial peptide
- OMP:0007174 ! increased resistance to antimicrobial peptide
- OMP:0007249 ! decreased resistance to a chemical
- OMP:0007250 ! increased resistance to a chemical
- OMP:0007363 ! decreased resistance to a nucleoside
- OMP:0007370 ! decreased resistance to an acridine
- OMP:0007377 ! decreased resistance to alkylating agent
- OMP:0007385 ! decreased resistance benzamides
- OMP:0007500 ! decreased resistance to an epoxide
- OMP:0007879 ! decreased resistance to an antimicrobial agent
