PMID:23452849
| Citation |
Mercier, R, Kawai, Y and Errington, J (2013) Excess membrane synthesis drives a primitive mode of cell proliferation. Cell 152:997-1007 |
|---|---|
| Abstract |
The peptidoglycan cell wall is a hallmark of the bacterial subkingdom. Surprisingly, many modern bacteria retain the ability to switch into a wall-free state called the L-form. L-form proliferation is remarkable in being independent of the normally essential FtsZ-based division machinery and in occurring by membrane blebbing and tubulation. We show that mutations leading to excess membrane synthesis are sufficient to drive L-form division in Bacillus subtilis. Artificially increasing the cell surface area to volume ratio in wild-type protoplasts generates similar shape changes and cell division. Our findings show that simple biophysical processes could have supported efficient cell proliferation during the evolution of early cells and provide an extant biological model for studying this problem. |
| Links |
PubMed Online version:10.1016/j.cell.2013.01.043 |
| Keywords |
Bacillus subtilis/cytology; Bacillus subtilis/metabolism; Bacterial Proteins/genetics; Bacterial Proteins/metabolism; Cell Division; Cell Membrane/metabolism; Cell Proliferation; Cell Wall/metabolism; Fatty Acid Synthetase Complex/genetics; Fatty Acid Synthetase Complex/metabolism; L Forms/cytology; L Forms/metabolism; Malonyl Coenzyme A/metabolism; Membrane Proteins/genetics; Membrane Proteins/metabolism; Peptidoglycan/metabolism; Polymorphism, Single Nucleotide; Protoplasts/metabolism |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
| edit table |
Notes
References
See Help:References for how to manage references in OMPwiki.
