PMID:2168148

Citation	Yoshida, H, Bogaki, M, Nakamura, M and Nakamura, S (1990) Quinolone resistance-determining region in the DNA gyrase gyrA gene of Escherichia coli.Antimicrob. Agents Chemother. 34:1271-2
Abstract	Nucleotide sequence analysis of the gyrA genes of 10 spontaneous quinolone-resistant gyrA mutants of Escherichia coli KL16, including four mutants examined previously, disclosed that quinolone resistance was caused by a point mutation within the region between amino acids 67 and 106, especially in the vicinity of amino acid 83, of the GyrA protein.
Links	PubMed
Keywords	4-Quinolones; Anti-Infective Agents; DNA Topoisomerases, Type II; Drug Resistance, Microbial; Escherichia coli; Mutation
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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: escherichia coli Strain: k-12 Substrain: KL16	Genotype of Reference Strain: gyrA Genotype of Experimental Strain : gyrA mutation in N-112	Reference Condition:					Table 1. mutation occurred at Amino Acid 83. similar strains: N-118, N-119, N-51, and P-18
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