PMID:400782

Citation	Bagdasarian, MM, Izakowska, M and Bagdasarian, M (1977) Suppression of the DnaA phenotype by mutations in the rpoB cistron of ribonucleic acid polymerase in Salmonella typhimurium and Escherichia coli. J. Bacteriol. 130:577-82
Abstract	A class of mutations that confer resistance to rifampin in Salmonella typhimurium and Escherichia coli also suppresses the thermosensitivity of chromosome initiation in dnaA mutants. Ribonucleic acid polymerase is resistant to rifampin in vitro in these suppressive mutants, and the suppressors of dnaA cannot be separated from the rpoB mutations by transduction. It is concluded, therefore, that certain rpoB mutations may suppress the DnaA phenotype.
Links	PubMed PMC235255
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Main Points of the Paper

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• Mutations in rpoB suppress a dnaA phenotype.

Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: EC3 NCBI Taxon ID: 83333	Genotype of Reference Strain: dnaA Genotype of Experimental Strain : dnaA46 in strain EC8	Reference Condition:					Increased resistance to rifampin. Table 2.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: EC3 NCBI Taxon ID: 83333	Genotype of Reference Strain: dnaA rpoB Genotype of Experimental Strain : dnaA46 rpoB706 in strain EC8	Reference Condition: non permissive temp (42.5C) of the single mutant dnaA					DnaA1 Mutant is unable to grow at 42.5C, mutation in rpoB suppresses thermosensitivity allowing the strain to grow at 42.5C.
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References

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