PMID:23224554

Citation	Al Mamun, AA , Lombardo, MJ , Shee, C , Lisewski, AM , Gonzalez, C , Lin, D , Nehring, RB , Saint-Ruf, C , Gibson, JL , Frisch, RL , Lichtarge, O , Hastings, PJ and Rosenberg, SM (2012) Identity and function of a large gene network underlying mutagenic repair of DNA breaks. Science 338:1344-8
Abstract	Mechanisms of DNA repair and mutagenesis are defined on the basis of relatively few proteins acting on DNA, yet the identities and functions of all proteins required are unknown. Here, we identify the network that underlies mutagenic repair of DNA breaks in stressed Escherichia coli and define functions for much of it. Using a comprehensive screen, we identified a network of ≥93 genes that function in mutation. Most operate upstream of activation of three required stress responses (RpoS, RpoE, and SOS, key network hubs), apparently sensing stress. The results reveal how a network integrates mutagenic repair into the biology of the cell, show specific pathways of environmental sensing, demonstrate the centrality of stress responses, and imply that these responses are attractive as potential drug targets for blocking the evolution of pathogens.
Links	PubMed Online version:10.1126/science.1226683
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Materials and Methods Used

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Phenotype Annotations

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Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes	Status
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: srlA+ Genotype of Experimental Strain : srlA777(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ybjT+ Genotype of Experimental Strain : ybjT770(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: treR+ Genotype of Experimental Strain : treR788(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC755(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC750::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ytjB Genotype of Experimental Strain : ytjB(P)::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: arcA Genotype of Experimental Strain : arcA(P)::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ligA Genotype of Experimental Strain : ligA(P)::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaG Genotype of Experimental Strain : apaG762(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: phoU Genotype of Experimental Strain : phoU755(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ihfA+ Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE+ Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yfjL+ Genotype of Experimental Strain : yfjL(P)::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lrp+ Genotype of Experimental Strain : Irp787(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: malL+ Genotype of Experimental Strain : mall768(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrA+ Genotype of Experimental Strain : acrA748(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: trxB+ Genotype of Experimental Strain : trxB786(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fre+ Genotype of Experimental Strain : fre784(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cspC+ Genotype of Experimental Strain : cspC747(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: barA+ Genotype of Experimental Strain : barA784(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ifhA+ Genotype of Experimental Strain : ihfA786(del)FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). A strong mutation, SIM was reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiA+ Genotype of Experimental Strain : ubiA::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiE+ Genotype of Experimental Strain : ubiE778(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq+ Genotype of Experimental Strain : hfq722(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoJ+ Genotype of Experimental Strain : nuoJ762(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC+ Genotype of Experimental Strain : nuoC768(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoL+ Genotype of Experimental Strain : nuoL760(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiH Genotype of Experimental Strain : ubiH758(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbA Genotype of Experimental Strain : dsbA723(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH Genotype of Experimental Strain : nuoH764(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yifE Genotype of Experimental Strain : yifE782(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rppH Genotype of Experimental Strain : rppH754(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpoE Genotype of Experimental Strain : rpoE2072::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: prc Genotype of Experimental Strain : prc755(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lon Genotype of Experimental Strain : lon725(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nagC Genotype of Experimental Strain : nagC725(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG Genotype of Experimental Strain : nuoG::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: rbsK Genotype of Experimental Strain : rbsK781(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hemL Genotype of Experimental Strain : hemL::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pepP Genotype of Experimental Strain : pepP759(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstB Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiX Genotype of Experimental Strain : ubiX732(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hdfR Genotype of Experimental Strain : hdfR785(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	A Stress Induced Mutagenesis phenotype (SIM). The mutation caused a significant decrease in SIM, with mutant frequency being reduced by over 90 percent of wild type levels. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: zncC Genotype of Experimental Strain : znuC783(del)::FRT	Reference Condition:	0005301	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoK Genotype of Experimental Strain : nuoK761(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgi Genotype of Experimental Strain : pgi721(del)FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ygfA Genotype of Experimental Strain : ygfA763(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yigP Genotype of Experimental Strain : yigP::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh Genotype of Experimental Strain : mdh761(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyaA Genotype of Experimental Strain : cyaA751(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: tatC Genotype of Experimental Strain : tatC781(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: glnK Genotype of Experimental Strain : glnK736(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhB Genotype of Experimental Strain : sdhB774(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqiC Genotype of Experimental Strain : yqiC737(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaH Genotype of Experimental Strain : apaH761(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA Genotype of Experimental Strain : cyoA789(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hscB Genotype of Experimental Strain : hscB773(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoD Genotype of Experimental Strain : cyoD786(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: dsbC Genotype of Experimental Strain : dsbC744(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstC Genotype of Experimental Strain : pstC758(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgl Genotype of Experimental Strain : pgl739(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: argR Genotype of Experimental Strain : argR762(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: fru Genotype of Experimental Strain : fruR786(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speE Genotype of Experimental Strain : speE739(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhD Genotype of Experimental Strain : sdhD772(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: cysD Genotype of Experimental Strain : cysD(P)::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: speD+ Genotype of Experimental Strain : speD738(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: proL Genotype of Experimental Strain : proL::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: lipB Genotype of Experimental Strain : lipB769(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA782 Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiD Genotype of Experimental Strain : ubiD::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yhhK Genotype of Experimental Strain : yhhK::Tn10dCam	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: metJ Genotype of Experimental Strain : metJ725(del)::FRTKanFRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Decreased stress-induced mutagenesis (SIM) phenotype. Mutation Rate was comparatively weak, to other strains, with decrease only happening in 33-67% of wild type population.
a mutation or genetic difference within a strain	Taxon: Escherihia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: hscB Genotype of Experimental Strain : hscB773(del)::FRT	Reference Condition:	0005031	decreased stress induced mutagenesis	0000178	in vivo assay evidence	Stress Induced Mutagenesis Phenotype, the mutation caused a significant decrease in SIM with mutant frequency being decreased by 68 to 89 percent of the wild type. See table S3 for full experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yjcC Genotype of Experimental Strain : yjcC755(del)::FRTKanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S1 & S7.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ligA Genotype of Experimental Strain : ligA(P)::Tn10dCam	Reference Condition:					An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: yqgE Genotype of Experimental Strain : yqgE723(del)::FRTKanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrY Genotype of Experimental Strain : uvrY760(del)::FRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstB Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgI Genotype of Experimental Strain : pgl739(del)::FRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR4562 NCBI Taxon ID: 83333	Genotype of Reference Strain: ldcA Genotype of Experimental Strain : idcA782(del)::FRTKanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			An increase in UV Sensitivity. Supplemental Table S7 & S1.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrY Genotype of Experimental Strain : SMR6039 uvrY760(del)::FRTkanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: pgi Genotype of Experimental Strain : SMR6039 pgi721(del)FRTKanFRT	Reference Condition:	0005098	decreased resistance toward UV radiation			The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: lexA Genotype of Experimental Strain : SMR6039 lexA3(Ind-)MalB::Tn9	Reference Condition:	0005098	decreased resistance toward UV radiation			The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR6039 NCBI Taxon ID: 83333	Genotype of Reference Strain: recB Genotype of Experimental Strain : SMR6039 recB(del)::Kan	Reference Condition:	0005098	decreased resistance toward UV radiation			The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11941 NCBI Taxon ID: 83333	Genotype of Reference Strain: recC Genotype of Experimental Strain : SMR6039 recC::Tn10DCam	Reference Condition:					The mutation conferred a decrease in Spontaneous SOS-induction. See table S7 for a summary of experimental data.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT rpoS+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT rpoS746(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT apaH+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT apaH761(del)::FRTKanFRT	Reference Condition:	000720	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT cspC+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT cspC747(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT cyoA789(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT cyoD+ Genotype of Experimental Strain : SMR4562 cyoD786(del)::FRTKanFRT yiaG-yfp FRTcatFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT fre+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT fre784(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT glnK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT glnK736(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT hdfR+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT hdfR785(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT hfq722(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT metJ+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT metJ725(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT hscB+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT hscB773(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh+ Genotype of Experimental Strain : SMR4562 mdh761(del)::FRTKanFRT yiaG-yfp FRTcatFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC+ Genotype of Experimental Strain : SMR4562 nuoC768(del)::FRT yiaG-yfp FRTcatFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT nuoG::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoH764(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoJ+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoJ762(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoK761(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT nuoL+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT nuoL760(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: yiaG-yfp FRTcatFRT pgi+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT pgi721(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT rbsK+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT rbsK781(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT sdhD+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT sdhD772::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT sdhB+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT sdhB774(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT speD+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT speD738(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT speE+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT speE739(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 (=SMR4562 yiaG-yfp FRTcatFRT) NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiA+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT ubiA::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiD+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT ubiD::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiE+ Genotype of Experimental Strain : SMR4562 ubiE778(del)::FRT yiaG-yfp FRTcatFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiH+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT ubiH758(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT ubiX+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT ubiX732(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT yifE+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT yifE786(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT arcB+ Genotype of Experimental Strain : SMR4562 arcB738(del)::FRT yiaG-yfp FRTcatFRT	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation conferred a increase in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT arcA+ Genotype of Experimental Strain : SMR4562 arcA726(del)::FRT yiaG-yfp FRTcatFRT	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation conferred a increase in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT rssB+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRTcatFRT rssB::Tet	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation conferred a increase in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ rpoE+ Genotype of Experimental Strain : CAG45114 rpoE2072::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ apaH+ Genotype of Experimental Strain : CAG45114 apaH761(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ arcA+ Genotype of Experimental Strain : CAG45114 arcA726(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ cyoA+ Genotype of Experimental Strain : CAG45114 cyoA789(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ cyoD+ Genotype of Experimental Strain : CAG45114 cyoD786(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ fre+ Genotype of Experimental Strain : CAG45114 fre784(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ fruR+ Genotype of Experimental Strain : CAG45114 fruR786(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ hemL+ Genotype of Experimental Strain : CAG45114 hemL::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ lipB+ Genotype of Experimental Strain : CAG45114 lipB769(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ lon+ Genotype of Experimental Strain : CAG45114 lon725(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ lrp+ Genotype of Experimental Strain : CAG45114 lrp787(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ mdh+ Genotype of Experimental Strain : CAG45114 mdh761(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoC+ Genotype of Experimental Strain : CAG45114 nuoC768(del)::RTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoG+ Genotype of Experimental Strain : CAG45114 nuoG::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoH+ Genotype of Experimental Strain : CAG45114 nuoH764::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoJ+ Genotype of Experimental Strain : CAG45114 nuoJ762(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoK+ Genotype of Experimental Strain : CAG45114 nuoK761(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ nuoL+ Genotype of Experimental Strain : CAG45114 nuoL760(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ phoU+ Genotype of Experimental Strain : CAG45114 phoU755(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ pstB+ Genotype of Experimental Strain : CAG45114 pstB756(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ rppH+ Genotype of Experimental Strain : CAG45114 rppH754(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ pstC+ Genotype of Experimental Strain : CAG45114 pstC758(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ sdhB+ Genotype of Experimental Strain : CAG45114 sdhB774(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ sdhD+ Genotype of Experimental Strain : CAG45114 sdhD772(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ trxB+ Genotype of Experimental Strain : CAG45114 trxB786(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ubiA+ Genotype of Experimental Strain : CAG45114 ubiA::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ubiD+ Genotype of Experimental Strain : CAG45114 ubiD::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ubiE+ Genotype of Experimental Strain : CAG45114 ubiE778(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ubiH+ Genotype of Experimental Strain : CAG45114 ubiH758(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ubiX+ Genotype of Experimental Strain : CAG45114 ubiX732(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ygfA+ Genotype of Experimental Strain : CAG45114 ygfA763(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ ygfP+ Genotype of Experimental Strain : CAG45114 yigP::Tn10dCam	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ znuC+ Genotype of Experimental Strain : CAG45114 znuC783(del)::FRTKanFRT	Reference Condition:	0007120	decreased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigma E activity. See table S11 for experimental calculations and results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ arcB+ Genotype of Experimental Strain : CAG45114 arcB738(del)::FRTKanFRT	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation caused an increase in SigmaE. See table S11 for experiment results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ arcA+ Genotype of Experimental Strain : CAG45114 arcA726(del)::FRTKanFRT	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation caused an increase in SigmaE. See table S11 for experiment results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ rssB+ Genotype of Experimental Strain : CAG45114 rssB::Tet	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation caused an increase in SigmaE. See table S11 for experiment results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: CAG45114 NCBI Taxon ID: 83333	Genotype of Reference Strain: MG1655 lambda rpoHP3-lacZ rseA+ Genotype of Experimental Strain : CAG45114 rseA(del)::FRTKanFRT	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation caused an increase in SigmaE. See table S11 for experiment results.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR10582 NCBI Taxon ID: 83333	Genotype of Reference Strain: SMR4562 yiaG-yfp FRTcatFRT hemL+ Genotype of Experimental Strain : SMR4562 yiaG-yfp FRT hemL::Tn10dCam	Reference Condition:	0007121	increased transcription of sigma-factor dependent genes			The mutation conferred a decrease in sigmaS activity relative to the wild type. For experimental calculations refer to table S8.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12023 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrA+ Genotype of Experimental Strain : arcA::Tn10dCam	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11984 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrB+ Genotype of Experimental Strain : acrB747(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: PJH1276 NCBI Taxon ID: 83333	Genotype of Reference Strain: Irp+ Genotype of Experimental Strain : Irp787(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12220 NCBI Taxon ID: 83333	Genotype of Reference Strain: acrA+ Genotype of Experimental Strain : acrA784(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11989 NCBI Taxon ID: 83333	Genotype of Reference Strain: trxB+ Genotype of Experimental Strain : trxB786(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12007 NCBI Taxon ID: 83333	Genotype of Reference Strain: fre+ Genotype of Experimental Strain : fre784(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12232 NCBI Taxon ID: 83333	Genotype of Reference Strain: ptsB+ Genotype of Experimental Strain : pstB756(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11967 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiX+ Genotype of Experimental Strain : ubiX732(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13473 NCBI Taxon ID: 83333	Genotype of Reference Strain: phoU+ Genotype of Experimental Strain : phoU753(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12219 NCBI Taxon ID: 83333	Genotype of Reference Strain: lipB+ Genotype of Experimental Strain : lipB769(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12302 NCBI Taxon ID: 83333	Genotype of Reference Strain: cysD+ Genotype of Experimental Strain : cysD"(P)::Tn10dCam	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12252 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhD+ Genotype of Experimental Strain : sdhD772(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12240 NCBI Taxon ID: 83333	Genotype of Reference Strain: speE+ Genotype of Experimental Strain : speE739(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12002 NCBI Taxon ID: 83333	Genotype of Reference Strain: fruR+ Genotype of Experimental Strain : fruR786(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12236 NCBI Taxon ID: 83333	Genotype of Reference Strain: znuA+ Genotype of Experimental Strain : znuA782(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12071 NCBI Taxon ID: 83333	Genotype of Reference Strain: pstC+ Genotype of Experimental Strain : pstC758(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12574 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoD+ Genotype of Experimental Strain : cyoD758(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12570 NCBI Taxon ID: 83333	Genotype of Reference Strain: cyoA+ Genotype of Experimental Strain : cyoA789(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11990 NCBI Taxon ID: 83333	Genotype of Reference Strain: apaH+ Genotype of Experimental Strain : apaH761(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12332 NCBI Taxon ID: 83333	Genotype of Reference Strain: sdhB+ Genotype of Experimental Strain : sdhB774(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12008 NCBI Taxon ID: 83333	Genotype of Reference Strain: tatC+ Genotype of Experimental Strain : tatC781(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12060 NCBI Taxon ID: 83333	Genotype of Reference Strain: mdh+ Genotype of Experimental Strain : mdh(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11980 NCBI Taxon ID: 83333	Genotype of Reference Strain: yigP+ Genotype of Experimental Strain : yigP::Tn10dCam	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12316 NCBI Taxon ID: 83333	Genotype of Reference Strain: ygfA+ Genotype of Experimental Strain : ygfA763(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13653 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoK+ Genotype of Experimental Strain : nuoK761(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13653 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoK+ Genotype of Experimental Strain : nuoK761(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12235 NCBI Taxon ID: 83333	Genotype of Reference Strain: hdfR+ Genotype of Experimental Strain : hdfR785(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13640 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoG+ Genotype of Experimental Strain : nuoG::Tn10dCam	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12254 NCBI Taxon ID: 83333	Genotype of Reference Strain: Ion+ Genotype of Experimental Strain : Ion725(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR5236 NCBI Taxon ID: 83333	Genotype of Reference Strain: rpoE+ Genotype of Experimental Strain : rpoE2072::Tn10dCam	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12210 NCBI Taxon ID: 83333	Genotype of Reference Strain: rppH+ Genotype of Experimental Strain : rppH754(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13654 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoH+ Genotype of Experimental Strain : nuoH764(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12260 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiH+ Genotype of Experimental Strain : ubiH758(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12223 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoC+ Genotype of Experimental Strain : nuoC768(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR13652 NCBI Taxon ID: 83333	Genotype of Reference Strain: nuoJ+ Genotype of Experimental Strain : nuoJ762(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12261 NCBI Taxon ID: 83333	Genotype of Reference Strain: hfq+ Genotype of Experimental Strain : hfq722(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12242 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiE+ Genotype of Experimental Strain : ubiE778(del)::FRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR12311 NCBI Taxon ID: 83333	Genotype of Reference Strain: ubiA+ Genotype of Experimental Strain : ubiA::Tn10dCAM	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: SMR11971 NCBI Taxon ID: 83333	Genotype of Reference Strain: ifhA+ Genotype of Experimental Strain : ifhA786(del)::FRTKanFRT	Reference Condition:	0005113	decreased resistance to SDS-EDTA stress			The mutation conferred an increased sensitivity to SDS-EDTA.
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Notes

• Reminder to indicate Stationary phase where it is necessary on both ompwiki and ecoliwiki

References

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