PMID:16970815

Citation	Crowley, DJ, Boubriak, I, Berquist, BR, Clark, M, Richard, E, Sullivan, L, DasSarma, S and McCready, S (2006) The uvrA, uvrB and uvrC genes are required for repair of ultraviolet light induced DNA photoproducts in Halobacterium sp. NRC-1.Saline Syst. 2:11
Abstract	Sequenced archaeal genomes contain a variety of bacterial and eukaryotic DNA repair gene homologs, but relatively little is known about how these microorganisms actually perform DNA repair. At least some archaea, including the extreme halophile Halobacterium sp. NRC-1, are able to repair ultraviolet light (UV) induced DNA damage in the absence of light-dependent photoreactivation but this 'dark' repair capacity remains largely uncharacterized. Halobacterium sp. NRC-1 possesses homologs of the bacterial uvrA, uvrB, and uvrC nucleotide excision repair genes as well as several eukaryotic repair genes and it has been thought that multiple DNA repair pathways may account for the high UV resistance and dark repair capacity of this model halophilic archaeon. We have carried out a functional analysis, measuring repair capability in uvrA, uvrB and uvrC deletion mutants.
Links	PubMed Online version:10.1186/1746-1448-2-11
Keywords
edit table

Main Points of the Paper

Please summarize the main points of the paper.

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

See Help:AnnotationTable for details on how to edit this table.

Phenotype of	Taxon Information	Genotype Information (if known)	Condition Information	OMP ID	OMP Term Name	ECO ID	ECO Term Name	Notes
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrA Genotype of Experimental Strain : uvrA(del)	Reference Condition:	OMP:0000270	absence of growth	ECO:0000094	biological assay data	Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrB Genotype of Experimental Strain : uvrB(del)	Reference Condition:	0000270	absence of growth	0000094	biological assay data	Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, figure 2.
a mutation or genetic difference within a strain	Taxon: Escherichia coli Strain: K-12 Substrain: NCBI Taxon ID: 83333	Genotype of Reference Strain: uvrC Genotype of Experimental Strain : uvrC(del)	Reference Condition:	OMP:0000270	absence of growth	ECO:0000094	biological assay data	Deletion mutation causes hypersensitive to UV when irradiated and incubated in non-photoreactivating conditions, fig 2.
edit table

See Help:References for how to manage references in OMPwiki.