OMP ST:71014 ! Escherichia coli K-12 BW25113 ftsA(R286W)-kan

Strain Summary

Strain Name	Escherichia coli K-12 BW25113 ftsA(R286W)-kan
Synonyms	ECK0095-B-FTSA(R286W)-KAN-Allele (Nichols et al. 2011. Supplemental Table S2)
Taxon Information	Pangenome: Escherichia coli Subspecies and/or strain: K-12 NCBI Taxonomy ID: 83333
Genotype	DE(araD-araB)567 DE(rhaD-rhaB)568 F- Lambda- hsdR514 lacZ4787(del)(::rrnB-3) rph-1 ftsA(R286W)-kan
Strain Reference	PMID:21185072
Strain availability
Ancestry	parent:OMP ST:800 ! Escherichia coli K-12 BW25113
Annotated phenotypes
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Phenotype Annotation

Annotation ID	Qualifier	OMP ID	OMP term name	Relative phenotype information	Experimental condition	ECO ID	ECO term name	Reference	Annotation Extension	Notes
OMP_AN:37279		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27557 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:A22	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CID:2830968) A22	chemical concentration= 0.5 ug/ml normalized fitness= -5.75
OMP_AN:37280		OMP:0006044	decreased resistance to beta-lactam	Relative to: OMP_AN:27531 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Ampicillin	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:28971) Ampicillin	chemical concentration= 4 ug/ml normalized fitness= -4.19
OMP_AN:37281		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27561 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Bleomycin sulfate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:34582) Bleomycin sulfate	chemical concentration= 0.1 ug/ml normalized fitness= -4.17
OMP_AN:37282		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27549 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:CHIR-090	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:134107 CID:11546620) CHIR-090	chemical concentration= 0.05 ug/ml normalized fitness= -3.49
OMP_AN:37283		OMP:0006044	decreased resistance to beta-lactam	Relative to: OMP_AN:27534 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Cefoxitin sodium hydrate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:3501) Cefoxitin sodium hydrate	chemical concentration= 1 ug/ml normalized fitness= -4.29
OMP_AN:37284		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27514 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Chlorpromazine hydrochloride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:3649) Chlorpromazine hydrochloride	chemical concentration= 6 uM normalized fitness= -12.96
OMP_AN:37285		OMP:0007903	decreased resistance to bile acids	Relative to: OMP_AN:27585 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Cholate sodium hydrate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CID:23679061) Cholate sodium hydrate	chemical concentration= 0.1 % normalized fitness= -4.85
OMP_AN:37286		OMP:0007903	decreased resistance to bile acids	Relative to: OMP_AN:27586 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Deoxycholate sodium	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:9177) Deoxycholate sodium	chemical concentration= 2 % normalized fitness= -5.47
OMP_AN:37287		OMP:0007879	decreased resistance to an antimicrobial agent	Relative to: OMP_AN:27545 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Isoniazid	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:6030) Isoniazid	chemical concentration= 1 mM normalized fitness= -3.85
OMP_AN:37288		OMP:0006044	decreased resistance to beta-lactam	Relative to: OMP_AN:27537 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Mecillinam	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:51208) Mecillinam	chemical concentration= 0.06 ug/ml normalized fitness= -4.79
OMP_AN:37289		OMP:0006063	increased resistance to tetracycline	Relative to: OMP_AN:27523 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Minocycline hydrochloride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:50697) Minocycline hydrochloride	chemical concentration= 1 ug/ml normalized fitness= 3.24
OMP_AN:37290		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27510 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Mitomycin C	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:27504) Mitomycin C	chemical concentration= 0.1 ug/ml normalized fitness= -3.96
OMP_AN:37291		OMP:0007886	decreased resistance to a metal	Relative to: OMP_AN:27580 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Nickel stress-Ni(II)Cl2 hexahydrate	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:53542) Nickel stress-Ni(II)Cl2 hexahydrate	chemical concentration= 1 mM (LB) normalized fitness= -3.78
OMP_AN:37292		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27570 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Propidium iodide	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:51240) Propidium iodide	chemical concentration= 20 ug/ml normalized fitness= -3.35
OMP_AN:37293		OMP:0007896	decreased resistance to a surfactant	Relative to: OMP_AN:27582 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:SDS	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:8984) SDS	chemical concentration= 4 % normalized fitness= -6.33
OMP_AN:37294		OMP:0007896	decreased resistance to a surfactant	Relative to: OMP_AN:27583 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Triton X-100	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:9750) Triton X-100	chemical concentration= 0.03 % normalized fitness= -4.39
OMP_AN:37295		OMP:0007249	decreased resistance to a chemical	Relative to: OMP_AN:27568 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:(±)-Verapamil hydrochloride	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:53188) (±)-Verapamil hydrochloride	chemical concentration= 1 mM normalized fitness= -3.33
OMP_AN:37296		OMP:0006044	decreased resistance to beta-lactam	Relative to: OMP_AN:27596 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:Cefaclor	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (CHEBI:3478) Cefaclor	chemical concentration= 3 ug/ml normalized fitness= -3.79
OMP_AN:37297		OMP:0007008	decreased population growth at acidic pH	Relative to: OMP_AN:27622 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:MES-HOMOPIPES	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072	towards some (**SID:329817955 SID:57651422) MES-HOMOPIPES	chemical concentration= pH 4 normalized fitness= -5.68
OMP_AN:37298		OMP:0005098	decreased resistance to UV radiation	Relative to: OMP_AN:27619 Genotype differences: +lacZ4787(del)( +ftsA(R286W)-kan -lacZ4787(del) Condition differences: no differences	temperature:37C medium:LB agar medium:UV	ECO:0007005	high throughput direct assay evidence used in manual assertion	PMID:21185072		chemical concentration= 12 sec normalized fitness= -3.68
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References

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