Difference between revisions of "PMID:12769856"
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | !|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status | ||
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By mutating the amino acid ala at the 32 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | By mutating the amino acid ala at the 32 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | ||
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By mutating the amino acid ala at the 34 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | By mutating the amino acid ala at the 34 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | ||
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By mutating the amino acid ala at the 33 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | By mutating the amino acid ala at the 33 position, the ''umuD'C'' is deleted, causing hypersensitivity to UV radiation. | ||
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Latest revision as of 10:56, 16 April 2015
| Citation |
Morimatsu, K and Kowalczykowski, SC (2003) RecFOR proteins load RecA protein onto gapped DNA to accelerate DNA strand exchange: a universal step of recombinational repair.Mol. Cell 11:1337-47 |
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| Abstract |
Genetic evidence suggests that the RecF, RecO, and RecR (RecFOR) proteins participate in a common step of DNA recombination and repair, yet the biochemical event requiring collaboration of all three proteins is unknown. Here, we show that the concerted action of the RecFOR complex directs the loading of RecA protein specifically onto gapped DNA that is coated with single-stranded DNA binding (SSB) protein, thereby accelerating DNA strand exchange. The RecFOR complex recognizes the junction between the ssDNA and dsDNA regions and requires a base-paired 5' terminus at the junction. Thus, the RecFOR complex is a structure-specific mediator that targets recombinational repair to ssDNA-dsDNA junctions. This reaction reconstitutes the initial steps of recombinational gapped DNA repair and uncovers an event also common to the repair of ssDNA-tailed intermediates of dsDNA-break repair. We propose that the behavior of the RecFOR proteins is mimicked by functional counterparts that exist in all organisms. |
| Links | |
| Keywords |
Bacterial Proteins; Cell Nucleus; DNA; DNA Damage; DNA Repair; DNA, Single-Stranded; DNA-Binding Proteins; Escherichia coli Proteins; Eukaryotic Cells; Gene Rearrangement; Nucleoproteins; Prokaryotic Cells; Rec A Recombinases |
| edit table |
Main Points of the Paper
Please summarize the main points of the paper.
Materials and Methods Used
Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).
Phenotype Annotations
See Help:AnnotationTable for details on how to edit this table.
| Phenotype of | Taxon Information | Genotype Information (if known) | Condition Information | OMP ID | OMP Term Name | ECO ID | ECO Term Name | Notes | Status |
|---|---|---|---|---|---|---|---|---|---|
|
a mutation or genetic difference within a strain |
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|
|
By mutating the amino acid ala at the 32 position, the umuD'C is deleted, causing hypersensitivity to UV radiation. |
For a different article | ||||
|
a mutation or genetic difference within a strain |
|
|
|
By mutating the amino acid ala at the 34 position, the umuD'C is deleted, causing hypersensitivity to UV radiation. |
For a different article | ||||
|
a mutation or genetic difference within a strain |
|
|
|
By mutating the amino acid ala at the 33 position, the umuD'C is deleted, causing hypersensitivity to UV radiation. |
For a different article | ||||
| edit table |
Notes
References
See Help:References for how to manage references in OMPwiki.
