Difference between revisions of "PMID:186449"

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'''Cordaro, JC, Melton, T, Stratis, JP, Atagün, M, Gladding, C, Hartman, PE and Roseman, S'''  (1976) Fosfomycin resistance: selection method for internal and extended deletions of the phosphoenolpyruvate:sugar phosphotransferase genes of Salmonella typhimurium.''J. Bacteriol.'' '''128''':785-93
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!align=left  |Abstract
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Selection for resistance to the antibiotic fosfomycin (FOS; L-cis 1,2-epoxypropylphosphonic acid, a structural analogue of phosphoenolpyruvate) was used to isolate mutants carrying internal and extended deletions of varying lengths within the ptsHI operon of Salmonella typhimurium. Strains carrying "tight" ptsI point mutations and all mutants in which some or all of the ptsI gene was deleted were FOS resistant. In contrast, strains carrying ptsH point mutations were sensitive to FOS. Resistance to FOS appeared to result indirectly from catabolite repression of an FOS transport system, probably the sn-glycerol-3-phosphate transport system. Resistant ptsI mutants became sensitive to FOS when grown on D-glucose-6-phosphate, which induces an alternate transport system for FOS, or when grown in the presence of cyclic adenosine 3',5'-monophosphate. A detailed fine-structure map of the pts gene region is presented.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=186449 PubMed]
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Anti-Bacterial Agents; Biological Transport, Active; Chromosome Mapping; Chromosomes, Bacterial; Cyclic AMP; Drug Resistance, Microbial; Fosfomycin; Mutation; Operon; Phosphotransferases; Salmonella typhimurium
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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{|  id="E4fe382607af96"  class=" tableEdit Phenotype_Table_2" 
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!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status
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==Notes==
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==References==
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[[Category:Publication]]

Latest revision as of 15:21, 21 June 2012

Citation

Cordaro, JC, Melton, T, Stratis, JP, Atagün, M, Gladding, C, Hartman, PE and Roseman, S (1976) Fosfomycin resistance: selection method for internal and extended deletions of the phosphoenolpyruvate:sugar phosphotransferase genes of Salmonella typhimurium.J. Bacteriol. 128:785-93

Abstract

Selection for resistance to the antibiotic fosfomycin (FOS; L-cis 1,2-epoxypropylphosphonic acid, a structural analogue of phosphoenolpyruvate) was used to isolate mutants carrying internal and extended deletions of varying lengths within the ptsHI operon of Salmonella typhimurium. Strains carrying "tight" ptsI point mutations and all mutants in which some or all of the ptsI gene was deleted were FOS resistant. In contrast, strains carrying ptsH point mutations were sensitive to FOS. Resistance to FOS appeared to result indirectly from catabolite repression of an FOS transport system, probably the sn-glycerol-3-phosphate transport system. Resistant ptsI mutants became sensitive to FOS when grown on D-glucose-6-phosphate, which induces an alternate transport system for FOS, or when grown in the presence of cyclic adenosine 3',5'-monophosphate. A detailed fine-structure map of the pts gene region is presented.

Links

PubMed

Keywords

Anti-Bacterial Agents; Biological Transport, Active; Chromosome Mapping; Chromosomes, Bacterial; Cyclic AMP; Drug Resistance, Microbial; Fosfomycin; Mutation; Operon; Phosphotransferases; Salmonella typhimurium

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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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Notes

References

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