Difference between revisions of "PMID:24837471"

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'''Lee, JH, Kim, YG, Cho, HS, Ryu, SY, Cho, MH and Lee, J''' Coumarins reduce biofilm formation and the virulence of Escherichia coli O157:H7. ''Phytomedicine'' '''21''':1037-42
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!align=left align='left' bgcolor='#CCCCFF' |Abstract
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E. coli O157:H7 is the most common cause of hemorrhagic colitis, and no effective therapy exists for E. coli O157:H7 infection. Biofilm formation is closely related to E. coli O157:H7 infection and constitutes a mechanism of antimicrobial resistance. Hence, the antibiofilm or antivirulence approach provides an alternative to antibiotic strategies. Coumarin and its derivatives have a broad range of biological effects, and in this study, the antibiofilm activities of nine coumarins were investigated against E. coli O157:H7. Coumarin or umbelliferone at 50μg/ml was found to inhibit biofilm E. coli O157:H7 formation by more than 80% without affecting bacterial growth. Transcriptional analysis showed that coumarins repressed curli genes and motility genes in E. coli O157:H7, and these findings were in-line with observed reductions in fimbriae production, swarming motility, and biofilm formation. In addition, esculetin repressed Shiga-like toxin gene stx2 in E. coli O157:H7 and attenuated its virulence in vivo in the nematode Caenorhabditis elegans. These findings show that coumarins have potential use in antivirulence strategies against persistent E. coli O157:H7 infection.
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[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=24837471 PubMed]
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Online version:[http://dx.doi.org/10.1016/j.phymed.2014.04.008 10.1016/j.phymed.2014.04.008]
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Animals; Anti-Bacterial Agents/pharmacology; Biofilms/drug effects; Biofilms/growth & development; Caenorhabditis elegans/drug effects; Coumarins/pharmacology; Escherichia coli O157/drug effects; Escherichia coli O157/pathogenicity; Escherichia coli O157/physiology; Escherichia coli O157/ultrastructure; Gene Expression Profiling; Gene Expression Regulation, Bacterial/drug effects; Umbelliferones/pharmacology; Virulence/drug effects
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==Main Points of the Paper ==
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== Materials and Methods Used ==
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==Phenotype Annotations==
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==Notes==
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[[Category:Publication]]

Latest revision as of 14:10, 30 November 2016

Citation

Lee, JH, Kim, YG, Cho, HS, Ryu, SY, Cho, MH and Lee, J Coumarins reduce biofilm formation and the virulence of Escherichia coli O157:H7. Phytomedicine 21:1037-42

Abstract

E. coli O157:H7 is the most common cause of hemorrhagic colitis, and no effective therapy exists for E. coli O157:H7 infection. Biofilm formation is closely related to E. coli O157:H7 infection and constitutes a mechanism of antimicrobial resistance. Hence, the antibiofilm or antivirulence approach provides an alternative to antibiotic strategies. Coumarin and its derivatives have a broad range of biological effects, and in this study, the antibiofilm activities of nine coumarins were investigated against E. coli O157:H7. Coumarin or umbelliferone at 50μg/ml was found to inhibit biofilm E. coli O157:H7 formation by more than 80% without affecting bacterial growth. Transcriptional analysis showed that coumarins repressed curli genes and motility genes in E. coli O157:H7, and these findings were in-line with observed reductions in fimbriae production, swarming motility, and biofilm formation. In addition, esculetin repressed Shiga-like toxin gene stx2 in E. coli O157:H7 and attenuated its virulence in vivo in the nematode Caenorhabditis elegans. These findings show that coumarins have potential use in antivirulence strategies against persistent E. coli O157:H7 infection.

Links

PubMed Online version:10.1016/j.phymed.2014.04.008

Keywords

Animals; Anti-Bacterial Agents/pharmacology; Biofilms/drug effects; Biofilms/growth & development; Caenorhabditis elegans/drug effects; Coumarins/pharmacology; Escherichia coli O157/drug effects; Escherichia coli O157/pathogenicity; Escherichia coli O157/physiology; Escherichia coli O157/ultrastructure; Gene Expression Profiling; Gene Expression Regulation, Bacterial/drug effects; Umbelliferones/pharmacology; Virulence/drug effects

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Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status
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Notes

References

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