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<div style="font-size:172%; border:none; margin:0; padding:.1em; color:#000;">Welcome to [[OMPWiki:About|OMPWiki]],</div> | <div style="font-size:172%; border:none; margin:0; padding:.1em; color:#000;">Welcome to [[OMPWiki:About|OMPWiki]],</div> | ||
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Web-based community resource designed to display microbial phenotypes and the methods used to study them.<br /> | Web-based community resource designed to display microbial phenotypes and the methods used to study them.<br /> | ||
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Revision as of 15:12, 22 June 2011
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What are microbial phenotypes & why do they need an ontology?A phenotype is the expression of a genotype (i.e. the full genetic complement of an organism) in a given environment. For example, eye color, number of seeds per pod, and coat color are phenotypic traits that can be observed in flies, lupines, and ponies, respectively. Within an individual organism, both changes in genetic makeup, such as from bacterial conjugation, and variation in gene expression can result in different phenotypes under similar environmental conditions. Conversely, environmental variation can lead to different outcomes for genetically identical organisms, through variable gene expression. Myriad genetically and taxonomically diverse microbes exhibit countless variability in their morphological and physiological traits, both within and among species. Oftentimes these result in unique and exquisite manifestations, such as the symbiosis between the bioluminescent Vibrio fischeri bacterium and its squid host Euprymna scolopes. Characterization of phenotypes is critically important for medical microbial identification, and many unique biotechnological applications of microbes are rooted in phenotypes. Genetic manipulation with associated phenotypic characterization remains an important tool for determining protein function in microorganisms amenable to manipulation, such as Escherichia coli. To facilitate research in all of these areas, we are developing the Ontology of Microbial Phenotypes to allow for standardized capture of essential phenotypic information.
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