View source for PMID:3025879

{{RightTOC}}

<!--box uid=d41d8cd98f00b204e9800998ecf8427e.3273.R503c03e790078-->
<!--
******************************************************************************************
* 
*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. ** 
* 
****************************************************************************************** -->
{|   id="R503c03e790078"  class=" tableEdit PMID_info_table"  

|-
!align=left  |Citation
||
'''Rudd, KE and Menzel, R'''  (1987) his operons of Escherichia coli and Salmonella typhimurium are regulated by DNA supercoiling.''Proc. Natl. Acad. Sci. U.S.A.'' '''84''':517-21
|-
!align=left  |Abstract
||
The hisW mutations of Salmonella typhimurium are highly pleiotropic mutations that elevate his operon expression, reduce ilv gene expression, alter stable RNA metabolism, and confer defective growth properties. The hisW mutations are highly linked to a naladixic acid-resistant gyrA mutation of S. typhimurium. Multicopy recombinant plasmids containing the Escherichia coli gyrA gene are able to complement both the growth defects and the elevated his operon expression associated with the hisW mutations. We conclude that hisW mutations are alleles of the gyrA gene. The hisU1820 mutant of S. typhimurium exhibits many of the same phenotypes as hisW mutants. Several lines of evidence, including high transduction linkage to recF, suggest that hisU1820 is an allele of gyrB. Finally, well-characterized gyrA and gyrB alleles of E. coli are also his regulatory mutations. We propose that a wild-type degree of chromosomal superhelicity is required for maximal production of histidyl-tRNA and normal his operon regulation.
|-
!align=left  |Links
||
[http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=3025879 PubMed]

|-
!align=left  |Keywords
||
Alcohol Oxidoreductases; DNA Restriction Enzymes; DNA, Superhelical; Escherichia coli; Genes; Genes, Bacterial; Genes, Regulator; Genotype; Mutation; Operon; Salmonella typhimurium; Transduction, Genetic; beta-Galactosidase

|- class="tableEdit_footer" 
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.3273.R503c03e790078&page=3273&pagename={{FULLPAGENAMEE}}&type=1&template=PMID_info_table edit table]</span> ||
|}
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.3273.R503c03e790078-->

==Main Points of the Paper ==
{{LitSignificance}}

== Materials and Methods Used ==
{{LitMaterials}}

==Phenotype Annotations==
{{AnnotationTableHelp}}
<protect><!--box uid=d41d8cd98f00b204e9800998ecf8427e.3273.U503c03e7be482-->
<!--
******************************************************************************************
* 
*   ** PLEASE DON'T EDIT THIS TABLE DIRECTLY.  Use the edit table link under the table. ** 
* 
****************************************************************************************** -->
{|   id="U503c03e7be482"  class=" tableEdit Phenotype_Table_2"  
|-
!|Phenotype of!!Taxon Information!!Genotype Information (if known)!!Condition Information!!OMP ID!!OMP Term Name!!ECO ID!!ECO Term Name!!Notes!!Status

|- class="tableEdit_footer" 
|<span class="tableEdit_editLink plainlinks">[{{SERVER}}{{SCRIPTPATH}}?title=Special:TableEdit&id=d41d8cd98f00b204e9800998ecf8427e.3273.U503c03e7be482&page=3273&pagename={{FULLPAGENAMEE}}&type=0&template=Phenotype_Table_2 edit table]</span> || || || || || || || || ||
|}
<!--box uid=d41d8cd98f00b204e9800998ecf8427e.3273.U503c03e7be482--></protect>

==Notes==

==References==
{{RefHelp}}
<references/>


[[Category:Publication]]