PMID:6760806

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Citation

Jaffe, A, Chabbert, YA and Semonin, O (1982) Role of porin proteins OmpF and OmpC in the permeation of beta-lactams.Antimicrob. Agents Chemother. 22:942-8

Abstract

Mutants of Escherichia coli K-12 lacking major outer membrane proteins were obtained by selecting for resistance to the beta-lactam cefoxitin. Three classes of resistant strains were found: mutants in ompB, a regulatory locus for proteins OmpF and OmpC; mutants in ompF; and one mutant in tpo. The OmpF and OmpC proteins facilitate penetration of beta-lactams through the outer membrane.

Links

PubMed

Keywords

Anti-Bacterial Agents; Bacterial Outer Membrane Proteins; Bacterial Proteins; Carrier Proteins; Cell Membrane Permeability; Escherichia coli; Hexosyltransferases; Membrane Proteins; Microbial Sensitivity Tests; Muramoylpentapeptide Carboxypeptidase; Penicillin-Binding Proteins; Peptidyl Transferases; beta-Lactams

Main Points of the Paper

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Materials and Methods Used

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Phenotype Annotations

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Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B1466
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: ompF
  • Genotype of Experimental Strain : ompF1466
  • Reference Condition:
OMP:0000276

increased resistance to antimicrobial compound

Resistance to beta lactam ampicillin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B1466
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: ompF
  • Genotype of Experimental Strain : ompF1466
  • Reference Condition:
OMP:0000276

increased resistance to antimicrobial compound

Resistance to beta lactam Cefoxitin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B1436
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: ompB
  • Genotype of Experimental Strain : ompB1422
  • Reference Condition:
OMP:0000276

increased resistance to antimicrobial compound

Resistance to beta lactam Cefoxitin

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B1436
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: ompB
  • Genotype of Experimental Strain : ompB1422
  • Reference Condition:
OMP:0000276

increased resistance to antimicrobial compound

Resistance to beta lactam ampicillin


Notes

ECO: The term Solid medium (in vivo) is awaiting approval to add.

OMP:

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