From OMPwiki
Jump to: navigation, search

Jaffé, A, Chabbert, YA and Derlot, E (1983) Selection and characterization of beta-lactam-resistant Escherichia coli K-12 mutants.Antimicrob. Agents Chemother. 23:622-5


beta-Lactam-resistant mutants of Escherichia coli K-12 were selected by using 12 different beta-lactam derivatives. The mutants fell into three categories showing (i) altered permeation through reduction or loss of outer membrane porin proteins (including ompF, ompR, and envZ alleles); (ii) increase in the rate of synthesis of chromosomally mediated beta-lactamase; or (iii) defective synthesis or action of cyclic adenosine 3',5'-phosphate (cya and crp alleles).




Anti-Bacterial Agents; Drug Resistance, Microbial; Escherichia coli; Mutation; beta-Lactamases; beta-Lactams

Main Points of the Paper

Please summarize the main points of the paper.

Materials and Methods Used

Please list the materials and methods used in this paper (strains, plasmids, antibodies, etc).

Phenotype Annotations

See Help:AnnotationTable for details on how to edit this table.

Phenotype of Taxon Information Genotype Information (if known) Condition Information OMP ID OMP Term Name ECO ID ECO Term Name Notes Status

a mutation or genetic difference within a strain

  • Taxon: Escherichia coli
  • Strain: K-12
  • Substrain: B1389
  • NCBI Taxon ID: 83333
  • Genotype of Reference Strain: crp
  • Genotype of Experimental Strain : crp in strain B1558
  • Reference Condition:

increased resistance to antimicrobial compound

Resistance to Beta Lactams



See Help:References for how to manage references in OMPwiki.